2-(Bromomethyl)-4-methoxy-3,5-dimethylpyridine

Base Information

• Chemical Name: 2-(Bromomethyl)-4-methoxy-3,5-dimethylpyridine
• CAS No.: 780752-32-1
• Molecular Formula: C9H12BrNO
• Molecular Weight: 230.104
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30544260
• Nikkaji Number: J2.911.812D
• Wikidata: Q82421330
• Mol file: 780752-32-1.mol

Synonyms:2-(bromomethyl)-4-methoxy-3,5-dimethylpyridine;780752-32-1;2-Bromomethyl-3,5-dimethyl-4-methoxypyridine;DTXSID30544260;AKOS015851661;SB21543;A9849;2-[(DIETHYLAMINO)METHYL]CYCLOPENTANONEHYDROCHLORIDE

Chemical Property of 2-(Bromomethyl)-4-methoxy-3,5-dimethylpyridine

Chemical Property:

• PSA: 22.12000
• LogP: 2.60190
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 229.01023
• Heavy Atom Count: 12
• Complexity: 143

Purity/Quality:

98%min ^*data from raw suppliers

2-(Bromomethyl)-4-methoxy-3,5-dimethylpyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C(=C1OC)C)CBr

Technology Process of 2-(Bromomethyl)-4-methoxy-3,5-dimethylpyridine

There total 1 articles about 2-(Bromomethyl)-4-methoxy-3,5-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-methoxy-3,5-dimethylpyridin-2-yl)methanol (86604-78-6) → 4-methoxy-3,5-dimethyl-2-pyridinemethyl bromide (780752-32-1)

Guidance literature:

With hexabromoacetone; triphenylphosphine; In acetonitrile; at 40 ℃; for 0.833333h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.10.133

Reference yield: 85.0%

4-methoxy-3,5-dimethyl-2-pyridinemethyl bromide (780752-32-1) + 6-methoxy-1H-benzoimidazole-2-thiol (37052-78-1) → 6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole (73590-85-9)

Guidance literature:

4-methoxy-3,5-dimethyl-2-pyridinemethyl bromide; 6-methoxy-1H-benzoimidazole-2-thiol; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium hydroxide; In acetonitrile; for 0.5h;

DOI:10.1016/j.tetlet.2010.10.133

upstream raw materials:

(4-methoxy-3,5-dimethylpyridin-2-yl)methanol

Downstream raw materials:

6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole

Refernces