1-(2-chloro-5-fluoropyridin-3-yl)ethanone

Base Information

• Chemical Name: 1-(2-chloro-5-fluoropyridin-3-yl)ethanone
• CAS No.: 1203499-12-0
• Molecular Formula: C7H5ClFNO
• Molecular Weight: 173.5721032
• Hs Code.: 2933399990
• Mol file: 1203499-12-0.mol

Synonyms:1-(2-Chloro-5-fluoropyridin-3-yl)ethanone;1-(2-Chloro-5-fluoro-3-pyridinyl)ethanone

Chemical Property of 1-(2-chloro-5-fluoropyridin-3-yl)ethanone

Chemical Property:

• Boiling Point: 224.2±35.0℃ (760 Torr)
• Flash Point: 89.4±25.9℃
• PSA: 29.96000
• Density: 1.331±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 2.07670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-(2-Chloro-5-fluoropyridin-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-chloro-5-fluoropyridin-3-yl)ethanone

There total 2 articles about 1-(2-chloro-5-fluoropyridin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

methylmagnesium bromide (75-16-1) + 2-chloro-5-fluoro-N-methoxy-N-methylnicotinamide → 1-(2-chloro-5-fluoropyridin-3-yl)ethan-1-one (1203499-12-0)

Guidance literature:

In tetrahydrofuran; methanol; at -78 - 20 ℃; Inert atmosphere;

Reference yield:

2-chloro-5-fluoronicotinic acid (38186-88-8) → 1-(2-chloro-5-fluoropyridin-3-yl)ethan-1-one (1203499-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 20 °C

2: tetrahydrofuran; methanol / -78 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

methylmagnesium bromide

2-chloro-5-fluoronicotinic acid

Refernces