2-(bromomethyl)-4-chloro-1-methylbenzene

Base Information

• Chemical Name: 2-(bromomethyl)-4-chloro-1-methylbenzene
• CAS No.: 869721-21-1
• Molecular Formula: C8H8BrCl
• Molecular Weight: 219.509
• Hs Code.: 2903999090
• Mol file: 869721-21-1.mol

Synonyms:5-chloro-2-methyl-benzyl bromide;2-Methyl-5-chlorbenzylbromid;5-Chlor-2-methyl-benzylbromid;2-(3-FLUORO-BENZYLOXY)-BENZALDEHYDE;3-CHLORO-6-METHYLBENZYL BROMIDE;

Chemical Property of 2-(bromomethyl)-4-chloro-1-methylbenzene

Chemical Property:

• Boiling Point: 251.7±25.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.491±0.06 g/cm3(Predicted)
• LogP: 3.54330
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(Bromomethyl)-4-chloro-1-methylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(bromomethyl)-4-chloro-1-methylbenzene

There total 6 articles about 2-(bromomethyl)-4-chloro-1-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(5-chloro-2-methylphenyl)methanol (58966-29-3) → 5-chloro-2-methyl-benzyl bromide (869721-21-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

4-amino-o-xylene (95-64-7) → 5-chloro-2-methyl-benzyl bromide (869721-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HCl / Diazotization_.Behandlung der Diazoniumsalz-Loesung mit CuCl in der Waerme

2: bromine / 125 - 130 °C

With hydrogenchloride; bromine;

DOI:10.1039/jr9470000662

Reference yield:

5-chloro-2-methylbenzoic acid (7499-06-1) → 5-chloro-2-methyl-benzyl bromide (869721-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / -78 - 20 °C / Inert atmosphere

2: triphenylphosphine; carbon tetrabromide / diethyl ether / 1 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; diethyl ether;

upstream raw materials:

4-chloro-1,2-dimethylbenzene

(5-chloro-2-methylphenyl)methanol

4-amino-o-xylene

5-chloro-2-methylbenzaldehyde

Downstream raw materials:

Ethyl-2-methyl-5-chlorbenzylsulfid

Ethyl-2-methyl-5-chlorbenzylsulfon

C₂₃H₂₄ClN₃O₂

Refernces

• 1、 -. "Amine compound and a manufacturing method thereof, and use thereof". Paragraph 0082; 0083-0084. . Retrieved 2020/07/01.