(E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride

Base Information

• Chemical Name: (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride
• CAS No.: 661489-23-2
• Molecular Formula: C₁₁H₁₂N₂*(x)ClH
• Molecular Weight: 208.69
• Hs Code.: 2926909090
• Mol file: 661489-23-2.mol

Synonyms:(E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride; (E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile hydrochloride

Chemical Property of (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride

Chemical Property:

• Appearance/Colour: Pale Green Crystalline Solid
• Melting Point: 300 °C
• PSA: 49.81000
• LogP: 3.80558
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol, Toluene

Purity/Quality:

98%,99%, ^*data from raw suppliers

(E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (E)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile Hydrochloride can be used in the preparation of 5,6-substituted pyrimidines that can possibly inhibit HIV strains resistant to reverse transcriptase inhibitors.

Technology Process of (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride

There total 13 articles about (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-(4-amino-3,5-dimethylphenyl)acrylonitrile (500292-86-4,661489-22-1) → (2E)-3-(4-amino-3,5-dimethylphenyl)prop-2-enenitrile hydrochloride (661489-23-2)

Guidance literature:

With hydrogenchloride; In ethanol; di-isopropyl ether; water; isopropyl alcohol; at 60 ℃; for 1h;

Reference yield: 77.0%

3-(4-amino-3,5-dimethylphenyl)acrylonitrile (500292-86-4,661489-22-1) → 3-(4-amino-3,5-dimethylphenyl)acrylonitrile hydrochloride (500292-90-0,661489-23-2)

Guidance literature:

With hydrogenchloride; In ethanol; di-isopropyl ether; isopropyl alcohol; at 60 ℃; for 0.5h; Inert atmosphere;

Reference yield:

4-iodo-2,6-dimethylaniline (4102-53-8) + acrylonitrile (107-13-1,25014-41-9) → (2E)-3-(4-amino-3,5-dimethylphenyl)prop-2-enenitrile hydrochloride (661489-23-2)

Guidance literature:

4-iodo-2,6-dimethylaniline; acrylonitrile; With sodium acetate; palladium 10% on activated carbon; In N,N-dimethyl acetamide; at 20 - 140 ℃;

With hydrogenchloride; In ethanol; water; isopropyl alcohol; at 20 ℃;

upstream raw materials:

4-iodo-2,6-dimethylaniline

acrylonitrile

3-(4-amino-3,5-dimethylphenyl)acrylonitrile

2,6-dimethylaniline

Refernces

• 1、 -. "Pharmaceutical compositions comprising a basic drug compound, a surfactant, and a physiologically tolerable water soluble acid". . . Retrieved 2015/12/04.
• 2、 -. "RILPIVIRINE PROCESS". Paragraph 0024; 0049; 0050; 0051. . Retrieved 2014/09/30.