Tie2 kinase inhibitor

Base Information

• Chemical Name: Tie2 kinase inhibitor
• CAS No.: 948557-43-5
• Molecular Formula: C₂₆H₂₁N₃O₂S
• Molecular Weight: 439.538
• Mol file: 948557-43-5.mol

Synonyms:4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole;Tie2 kinase inhibitor;4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(Methylsulfinyl)phenyl]-1H-iMidazol-5-yl]pyridine;4-(5-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine

Chemical Property of Tie2 kinase inhibitor

Chemical Property:

• Boiling Point: 699.8±55.0 °C(Predicted)
• PKA: 9.53±0.10(Predicted)
• PSA: 87.08000
• Density: 1.39±0.1 g/cm3(Predicted)
• LogP: 6.57060
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: ≥22 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Purity/Quality:

99%+, ^*data from raw suppliers

4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tie2 kinase inhibitor. Tunica interna endothelial cell kinase 2 (Tie2, also known as angiopoietin-1 receptor or tek) is an endothelium-specific receptor tyrosine kinase important for the development of embryonic vasculature and for angiogenesis and vascular maintenance in adult tissues. Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM. It is 200-fold more potent for inhibition of Tie2 compared to p38. Tie2 kinase inhibitor has been shown to reduce angiogenesis in a Matrigel neovascularization assay and to delay tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models.[Cayman Chemical]

Technology Process of Tie2 kinase inhibitor

There total 1 articles about Tie2 kinase inhibitor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H21N3OS → (4-(5-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine) (948557-43-5)

Guidance literature:

With dipotassium peroxodisulfate; acetic acid; In water;

DOI:10.1016/j.bmcl.2007.06.068

Refernces