Potassium 1-methyl-4-trifluoroboratomethylpiperazine

Base Information

• Chemical Name: Potassium 1-methyl-4-trifluoroboratomethylpiperazine
• CAS No.: 1015484-22-6
• Molecular Formula: C6H13BF3N2.K
• Molecular Weight: 220.087
• Hs Code.: 2933599090
• Mol file: 1015484-22-6.mol

Synonyms:Potassium 1-methyl-4-trifluoroboratomethylpiperazine;POTASSIUM 1-METHYL-4-TRIFLUOROBORATEMETHYLPIPERAZINE;POTASSIUM TRIFLUORO[(4-METHYLPIPERAZIN-1-YL)METHYL]BORATE

Chemical Property of Potassium 1-methyl-4-trifluoroboratomethylpiperazine

Chemical Property:

• Melting Point: 119-121℃
• PSA: 6.48000
• LogP: 0.91450

Purity/Quality:

98%,99%, ^*data from raw suppliers

Potassium1-Methyl-4-trifluoroboratomethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Potassium 1-methyl-4-trifluoroboratomethylpiperazine

There total 1 articles about Potassium 1-methyl-4-trifluoroboratomethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-methyl-piperazine (109-01-3) + potassium bromomethyl trifluoroborate → 1-methyl-4-((trifluoro-λ4-boranyl)methyl)piperazine potassium (1015484-22-6)

Guidance literature:

In tetrahydrofuran; at 80 ℃; for 4h;

DOI:10.1021/acs.joc.0c02958

Reference yield: 89.0%

1-methyl-4-((trifluoro-λ4-boranyl)methyl)piperazine potassium (1015484-22-6) + 4-(5-chloro-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine (1253573-76-0) → N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-((4-methylpiperazin-1-yl)methyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine (1253573-82-8)

Guidance literature:

With palladium diacetate; caesium carbonate; XPhos; In tetrahydrofuran; water; at 140 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jm300184s

Reference yield: 87.0%

1-methyl-4-((trifluoro-λ4-boranyl)methyl)piperazine potassium (1015484-22-6) + 3-chloro-aniline (108-42-9) → 3-(4-methyl-piperazin-1-ylmethyl)-phenylamine (198281-55-9)

Guidance literature:

With C₅₂H₆₇ClFeNPPd; caesium carbonate; In tetrahydrofuran; water; at 80 ℃; for 12h;

DOI:10.1055/s-0030-1259331

upstream raw materials:

1-methyl-piperazine

Downstream raw materials:

N-(4-methoxybenzyl)-N'-methylpiperazine

C₁₁H₁₇N₃

C₁₂H₁₆N₄

1-benzyl-4-methylpiperazine

Refernces

• 1、 Lippa, Rhys A.,Battersby, David J.,Murphy, John A.,Barrett, Tim N.. "Synthesis of Arylethylamines via C(sp3)-C(sp3) Palladium-Catalyzed Cross-Coupling". . p. 3583 - 3604. Retrieved 2021/02/27.