(R)-Ketamine Hydrochloride

Base Information Edit

Chemical Name:(R)-Ketamine Hydrochloride
CAS No.:33795-24-3
Molecular Formula:C13H17Cl2NO
Molecular Weight:274.19
Hs Code.:
European Community (EC) Number:625-831-1
UNII:5F91OR6H84
DSSTox Substance ID:DTXSID90187455
Wikidata:Q27261960
Mol file:33795-24-3.mol

Synonyms:33795-24-3;(R)-Ketamine Hydrochloride;(-)-(R)-Ketamine Hydrochloride;Ketamine hydrochloride, L-;UNII-5F91OR6H84;(R)-(-)-Ketamine hydrochloride;5F91OR6H84;S-(+)-Ketamine hydrochloride;(2R)-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one hydrochloride;(2R)-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;hydrochloride;Arketamine HCl;(R)-(+)-Ketamine Hydrochloride;Arketamine hydrochloride;L-Ketamine hydrochloride;(R)-Ketamine (hydrochloride);DTXSID90187455;KETAMINE HYDROCHLORIDE, R-;KETAMINE HYDROCHLORIDE, (R)-;R-(-)-KETAMINE HYDROCHLORIDE;ARKETAMINE HYDROCHLORIDE [WHO-DD];Q27261960;(R)-(-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride;Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, hydrochloride, (R)-;CYCLOHEXANONE, 2-(2-CHLOROPHENYL)-2-(METHYLAMINO)-, HYDROCHLORIDE (1:1), (2R)-;CYCLOHEXANONE, 2-(O-CHLOROPHENYL)-2-(METHYLAMINO)-, HYDROCHLORIDE, (+)-

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of (R)-Ketamine Hydrochloride Edit

Chemical Property:

PSA：29.10000
LogP:4.09070
Storage Temp.:2-8°C
Solubility.:H2O: 200 mg/mL
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:273.0687196
Heavy Atom Count:17
Complexity:269

Purity/Quality:

Safty Information:

Pictogram(s): R22:; R36/37/38:; R40:;
Hazard Codes:Xn
Statements: 22-36/37/38-40
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1(CCCCC1=O)C2=CC=CC=C2Cl.Cl
Isomeric SMILES:CN[C@]1(CCCCC1=O)C2=CC=CC=C2Cl.Cl
Recent EU Clinical Trials:A randomized, placebo-controlled, double-blind study to assess the safety and efficacy of intravenous PCN-101 in treatment-resistant depression
Uses General anaesthetic

Technology Process of (R)-Ketamine Hydrochloride

There total 5 articles about (R)-Ketamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 87-69-4,138508-61-9
L-Tartaric acid

: 6740-88-1,100477-72-3,33643-46-8,33643-49-1
ketamine

: 33795-24-3
(+)-Ketamine hydrochloride

: (S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone tartrate

: 33643-47-9
(-)-Ketamine hydrochloride

Guidance literature:: L-Tartaric acid; ketamine; In water; acetone; for 0.5h; Reflux;

With sodium hydroxide; In water;

With hydrogenchloride; In ethyl acetate;
DOI:10.1021/acs.oprd.9b00436

Reference yield:

: C₁₃H₁₆ClNO*C₁₉H₁₆O₈

: 33795-24-3
(+)-Ketamine hydrochloride

Guidance literature:: C₁₃H₁₆ClNO*C₁₉H₁₆O₈; With sodium hydroxide; In dichloromethane; water; for 0.5h; pH=13 - 14; Large scale;

With hydrogenchloride; In ethanol; water; ethyl acetate; at 30 - 40 ℃; pH=2 - 3; Large scale;