1-(benzyloxy)-2-bromo-4-chlorobenzene

Base Information

• Chemical Name: 1-(benzyloxy)-2-bromo-4-chlorobenzene
• CAS No.: 151038-76-5
• Molecular Formula: C13H10BrClO
• Molecular Weight: 297.579
• Mol file: 151038-76-5.mol

Synonyms:5-chloro-2-benzyloxybromobenzene;benzyl 2-bromo-4-chlorophenyl ether;

Chemical Property of 1-(benzyloxy)-2-bromo-4-chlorobenzene

Chemical Property:

• Melting Point: 50-52 °C
• Boiling Point: 363.8±27.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.471±0.06 g/cm3(Predicted)
• LogP: 4.68150

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyloxy-2-bromo-4-chlorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(benzyloxy)-2-bromo-4-chlorobenzene

There total 3 articles about 1-(benzyloxy)-2-bromo-4-chlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-4-chlorophenol (695-96-5) + benzyl bromide (100-39-0) → 1-(benzyloxy)-2-bromo-4-chlorobenzene (151038-76-5)

Guidance literature:

With potassium carbonate;

DOI:10.1016/j.bmcl.2004.12.005

Reference yield: 90.0%

2-bromo-4-chlorophenol (695-96-5) + benzyl chloride (100-44-7) → 1-(benzyloxy)-2-bromo-4-chlorobenzene (151038-76-5)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1021/jo060271d

Reference yield:

2-bromo-4-chlorophenol (695-96-5) + benzyl bromide (100-39-0) → 2-bromo-4-chlorophenyl benzylether + 1-(benzyloxy)-2-bromo-4-chlorobenzene (151038-76-5)

Guidance literature:

With potassium hydroxide; sodium hydroxide; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dimethyl sulfoxide;

upstream raw materials:

2-bromo-4-chlorophenol

benzyl bromide

benzyl chloride

Downstream raw materials:

{5'-chloro-2'-[(phenylmethyl)-oxy]-2-biphenylyl}-boronic acid

2'-bromo-5-chloro-2-[(phenylmethyl)-oxy]-biphenyl

2-[2-(2-benzyloxy-5-chloro-phenyl)-thiophen-3-yl]-6-triisopropylsilanyloxymethyl-pyridine

1-(5-{3-[5-chloro-2-(phenylmethoxy)phenyl](2-thienyl)}(3-pyridyl))-2,2,2-trifluoroethan-1-ol

Refernces

• 1、 -. "BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE". Page/Page column 31-32. . Retrieved 2008/06/13.
• 2、 Ducharme, Yves,Blouin, Marc,Carriere, Marie-Claude,Chateauneuf, Anne,Cote, Bernard,Denis, Danielle,Frenette, Richard,Greig, Gillian,Kargman, Stacia,Lamontagne, Sonia,Martins, Evelyn,Nantel, Francois,O'Neill, Gary,Sawyer, Nicole,Metters, Kathleen M.,Friesen, Richard W.. "2,3-Diarylthiophenes as selective EP1 receptor antagonists". . p. 1155 - 1160. Retrieved 2007/10/03.