2-FLUORONITROBENZENE

Base Information

• Chemical Name: 2-FLUORONITROBENZENE
• CAS No.: 127723-77-7
• Molecular Formula: C₆H₄FNO₂
• Molecular Weight: 141.102
• Mol file: 127723-77-7.mol

Synonyms:2-FLUORONITROBENZENE

Chemical Property of 2-FLUORONITROBENZENE

Chemical Property:

• PSA: 45.82000
• LogP: 2.25710

Purity/Quality:

98.5% ^*data from raw suppliers

2-FLUORONITROBENZENE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORONITROBENZENE

There total 69 articles about 2-FLUORONITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

2-Chloronitrobenzene (88-73-3) → ortho-nitrofluorobenzene (1493-27-2,127723-77-7)

Guidance literature:

With potassium fluoride; polydiallyldimethylammonium chloride; In dimethyl sulfoxide; at 200 ℃; for 3h;

DOI:10.1016/j.jfluchem.2003.11.018

Reference yield: 76.8%

fluorobenzene (462-06-6) → 4-Fluoronitrobenzene (350-46-9,178603-76-4) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7)

Guidance literature:

With nitric acid; at 50 ℃; for 3h;

DOI:10.1039/c2ra21582a

Reference yield: 56.0%

o-nitroiodobenzene (609-73-4) → nitrobenzene (98-95-3,26969-40-4) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7)

Guidance literature:

o-nitroiodobenzene; With phenyllithium; In tetrahydrofuran; diethyl ether; cyclohexane; at -28 ℃; Flow reactor;

With 2-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide; In tetrahydrofuran; diethyl ether; cyclohexane; at -28 ℃; Flow reactor;

DOI:10.1002/asia.201201191

upstream raw materials:

fluorobenzene

nitro acetate

4-Fluoro-3-nitroaniline

2-Chloronitrobenzene

Downstream raw materials:

(Z)-1,2-bis(2-fluorophenyl)diazene 1-oxide

4-(3,4-Dimethoxy-phenyl)-1,2-dihydro-imidazo[1,2-a]quinoxaline 5-oxide

2,3,4,5,6-Pentafluor-2'-nitro-diphenylamin

2,3,4,5,6-Pentafluor-2'-nitro-diphenylether

Refernces

• 1、 Appelman, Evan H.,Basile, Louis J.,Hayatsu, Ryoichi. "THE REACTION OF FLUOROXYSULFATE, SO4F(1-), WITH AROMATIC COMPOUNDS: CATLYSIS BY ACIDS". . p. 189 - 198. Retrieved 1984.
• 2、 Laszlo, Pierre,Pennetreau, Pascal. "Vastly Improved Para Preference in the Nitration of Halobenzenes". . p. 2407 - 2410. Retrieved 1987.
• 3、 Sasaki, Koshi,Oishi, Mari,Imaki, Naoshi. "An improved method for fluoro-dediazoniation of arylamines substituted with polar groups". . p. 59 - 62. Retrieved 1996.
• 4、 Banks, R. Eric,Besheesh, Mohamed K.,Fraenk, Wolfgang,Klap?tke, Thomas M.. "1-Fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate: Synthesis, characterization, and ability to effect electrophilic aromatic substitution". . p. 229 - 232. Retrieved 2003.
• 5、 Aksenov, V.V.,Vlasov, V.M.,Moryakina, I.M.,Rodionov, P.P.,Fadeeva, V.P.,et al.. "INTERACTION OF CHLOROAROMATIC COMPOUNDS WITH ALKALI METAL FLUORIDES IN THE PRESENCE OF CROWN-ETHERS". . p. 73 - 88. Retrieved 1985.
• 6、 Fukuhara, Tsuyoshi,Yoneda, Norihiko,Suzuki, Akira. "A Facile Preparation of Fluoropyridines from Aminopyridines via Diazotation and Fluorodediazoniation in HF or HF-Pyridine Solutions". . p. 435 - 438. Retrieved 1988.
• 7、 -. "Method for synthesizing nitro (hetero) aromatic hydrocarbon". Paragraph 0082-0084; 0097-0099. . Retrieved 2022/04/08.
• 8、 Xu, Peng,López-Rojas, Priscila,Ritter, Tobias. "Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination". supporting information. p. 5349 - 5354. Retrieved 2021/05/05.