Benzenemethanamine, 3-chloro-.alpha.-ethyl-, (.alpha.R)-

Base Information

• Chemical Name: Benzenemethanamine, 3-chloro-.alpha.-ethyl-, (.alpha.R)-
• CAS No.: 1168139-52-3
• Molecular Formula: C₉H₁₂ClN
• Molecular Weight: 169.654
• Mol file: 1168139-52-3.mol

Synonyms:Benzenemethanamine, 3-chloro-α-ethyl-, (αR)-;

Chemical Property of Benzenemethanamine, 3-chloro-.alpha.-ethyl-, (.alpha.R)-

Chemical Property:

• Boiling Point: 235.0±15.0 °C(Predicted)
• PKA: 9.03±0.10(Predicted)
• PSA: 26.02000
• Density: 1.093±0.06 g/cm3(Predicted)
• LogP: 3.45010
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

(R)-1-(3-Chlorophenyl)propan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanamine, 3-chloro-.alpha.-ethyl-, (.alpha.R)-

There total 6 articles about Benzenemethanamine, 3-chloro-.alpha.-ethyl-, (.alpha.R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethylmagnesium bromide (925-90-6) + m-Chlorobenzaldehyde (587-04-2) → 1-(3-chlorophenyl)propylamine (40023-86-7,1075715-57-9,1168139-52-3)

Guidance literature:

With ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at 20 ℃; for 24h; Heating / reflux;

Reference yield: 66.0%

ethylmagnesium bromide (925-90-6) → 1-(3-chlorophenyl)propylamine (40023-86-7,1075715-57-9,1168139-52-3)

Guidance literature:

m-Chlorobenzaldehyde; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.333333h;

ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; for 24h; Heating / reflux;

Reference yield:

3'-chloro-propiophenone (34841-35-5) → 1-(3-chlorophenyl)propylamine (40023-86-7,1075715-57-9,1168139-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH*HCl; NaOAc / methanol / 18 h / 20 °C

2: H₂; thiophene; NH₃ / RaNi / methanol

With thiophene; hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; RaNi; In methanol;

DOI:10.1016/j.bmcl.2004.11.064

upstream raw materials:

3'-chloro-propiophenone

ethylmagnesium bromide

m-Chlorobenzaldehyde

3-chloro-benzonitrile

Refernces

• 1、 Van Lommen, Guy,Doyon, Julien,Coesemans, Erwin,Boeckx, Staf,Cools, Marina,Buntinx, Mieke,Hermans, Bart,VanWauwe, Jean. "2-Mercaptoimidazoles, a new class of potent CCR2 antagonists". . p. 497 - 500. Retrieved 2007/10/03.
• 2、 -. "ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS". Page/Page column 201. . Retrieved 2010/02/13.