1H-Indole-3-carboxylic acid, 1-methyl-, propyl ester

Base Information

• Chemical Name: 1H-Indole-3-carboxylic acid, 1-methyl-, propyl ester
• CAS No.: 1033693-02-5
• Molecular Formula: C13H15NO2
• Molecular Weight: 217.2637
• Mol file: 1033693-02-5.mol

Synonyms:Methanol,1-propoxy;propyl 1-methylindole-3-carboxylate;propoxy-methanol;

Chemical Property of 1H-Indole-3-carboxylic acid, 1-methyl-, propyl ester

Chemical Property:

• PSA: 31.23000
• LogP: 2.74510

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-3-carboxylic acid, 1-methyl-, propyl ester

There total 2 articles about 1H-Indole-3-carboxylic acid, 1-methyl-, propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

propan-1-ol (71-23-8) + 1-methylindole (603-76-9) + carbon monoxide (201230-82-2) → propyl 1-methylindole-3-carboxylate (1033693-02-5)

Guidance literature:

With dipotassium peroxodisulfate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In toluene; at 110 ℃; for 24h; under 760.051 Torr; regioselective reaction;

DOI:10.1039/c1cc15143f

Reference yield:

indole (120-72-9) → propyl 1-methylindole-3-carboxylate (1033693-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / diethyl ether / 24 h / 0 °C

2: chloro(1,5-cyclooctadiene)rhodium(I) dimer; dipotassium peroxodisulfate / toluene / 24 h / 110 °C / 760.05 Torr

With dipotassium peroxodisulfate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium tert-butylate; In diethyl ether; toluene;

DOI:10.1039/c1cc15143f

upstream raw materials:

indole

propan-1-ol

1-methylindole

carbon monoxide

Refernces