N-(1-benzyl-4-cyano-1H-1,2,3-triazol-5-yl)ethanediamide

Base Information

• Chemical Name: N-(1-benzyl-4-cyano-1H-1,2,3-triazol-5-yl)ethanediamide
• CAS No.: 77976-40-0
• Molecular Formula: C12H10N6O2
• Molecular Weight: 270.25
• Mol file: 77976-40-0.mol

Synonyms:

Chemical Property of N-(1-benzyl-4-cyano-1H-1,2,3-triazol-5-yl)ethanediamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.48g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-benzyl-4-cyano-1H-1,2,3-triazol-5-yl)ethanediamide

There total 2 articles about N-(1-benzyl-4-cyano-1H-1,2,3-triazol-5-yl)ethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-benzyl-4-ethoxalylamino-3H-1,2,3-triazole-5-carbonitrile (77976-38-6) → 3-benzyl-4-oxamoylamino-3H-1,2,3-triazole-5-carbonitrile (77976-40-0)

Guidance literature:

With ammonium hydroxide; In ethanol; at 20 ℃;

DOI:10.1039/P19810000887

Reference yield:

5-amino-1-benzyl-1H-[1,2,3]triazole-4-carbonitrile (20271-35-6) → 3-benzyl-4-oxamoylamino-3H-1,2,3-triazole-5-carbonitrile (77976-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / pyridine / 1 h / 1 °C

2: 90 percent / 3N NH₃ / ethanol / 20 °C

With pyridine; ammonium hydroxide; In ethanol;

DOI:10.1039/P19810000887

Reference yield: 85.0%

3-benzyl-4-oxamoylamino-3H-1,2,3-triazole-5-carbonitrile (77976-40-0) → 4-amino-3-benzyl-5-oxamoylaminomethyl-3H-1,2,3-triazole (77976-42-2)

Guidance literature:

With ammonium hydroxide; hydrogen; nickel; In ethanol; at 70 ℃; for 18h; under 3040 Torr;

DOI:10.1039/P19810000887

upstream raw materials:

3-benzyl-4-ethoxalylamino-3H-1,2,3-triazole-5-carbonitrile

5-amino-1-benzyl-1H-[1,2,3]triazole-4-carbonitrile

Downstream raw materials:

4-amino-3-benzyl-5-oxamoylaminomethyl-3H-1,2,3-triazole

Refernces