2-(perfluorophenyl)ethanamine

Base Information

• Chemical Name: 2-(perfluorophenyl)ethanamine
• CAS No.: 1583-76-2
• Molecular Formula: C8H6F5N
• Molecular Weight: 211.134
• Mol file: 1583-76-2.mol

Synonyms:2-(Pentafluorophenyl)ethylaMine

Chemical Property of 2-(perfluorophenyl)ethanamine

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(perfluorophenyl)ethanamine

There total 11 articles about 2-(perfluorophenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(pentafluorophenyl)acetonitrile (653-30-5) → 2-(2,3,4,5,6-pentafluorophenyl)ethan-1-amine (1583-76-2)

Guidance literature:

(pentafluorophenyl)acetonitrile; With aluminum (III) chloride; lithium aluminium tetrahydride; In diethyl ether; at 20 ℃;

With water; In diethyl ether;

Reference yield:

(pentafluorophenyl)acetonitrile (653-30-5) → 2-(2,3,4,5,6-pentafluorophenyl)ethan-1-amine (1583-76-2) + Bis(pentafluorophenylethyl)amine

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; under 760 - 2280 Torr; Title compound not separated from byproducts; Ambient temperature;

DOI:10.1016/0022-1139(94)03202-B

Reference yield:

(bromomethyl)pentafluorobenzene (1765-40-8) → 2-(2,3,4,5,6-pentafluorophenyl)ethan-1-amine (1583-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. ethanol

2: LiAlH₄

With lithium aluminium tetrahydride; In ethanol;

DOI:10.1039/jr9610000808

upstream raw materials:

(pentafluorophenyl)acetonitrile

bromopentafluorobenzene

perfluorobenzaldehyde

1,2,3,4,5-pentafluoro-6-iodobenzene

Downstream raw materials:

N,N'-bis(perfluorophenethyl)-1,2,5,6-naphthalenetetracarboxyl diimide

N,N'-di(2-(perfluorophenyl)ethyl)pyromellitic diimide

N,N-dimethyl-2,3,4,5,6-pentafluorobenzeneethanamine

N,N'-bis(pentafluorophenylethyl)-1,6,7,12-tetrachloroperylene-3,4:9,10-tetracarboxylic acid bisimide

Refernces

• 1、 James Gruver,Onyango, Evans O.,Gribble, Gordon W.. "The synthesis of 7,8,9,10-Tetrafluoroellipticine". . p. 144 - 152. Retrieved 2018.
• 2、 Giese, Michael,Albrecht, Markus,Wiemer, Katharina,Valkonen, Arto,Rissanen, Kari. "Controlling the position of anions relative to a pentafluorophenyl group". . p. 1368 - 1372. Retrieved 2012/11/07.