Nicotinonitrile, 4-hydroxy- (7CI)

Base Information

• Chemical Name: Nicotinonitrile, 4-hydroxy- (7CI)
• CAS No.: 89324-16-3
• Molecular Formula: C₆H₄N₂O
• Molecular Weight: 120.111
• Hs Code.: 2933399090
• Mol file: 89324-16-3.mol

Synonyms:4-Hydroxy-1,4-dihydropyridine-3-carbonitrile;4-hydroxynicotinonitrile;

Chemical Property of Nicotinonitrile, 4-hydroxy- (7CI)

Chemical Property:

• Vapor Pressure: 0.0302mmHg at 25°C
• Boiling Point: 244.6ºC at 760 mmHg
• Flash Point: 101.7ºC
• PSA: 56.91000
• Density: 1.27g/cm3
• LogP: 0.65888
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Hydroxynicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Nicotinonitrile, 4-hydroxy- (7CI)

There total 4 articles about Nicotinonitrile, 4-hydroxy- (7CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

zinc(II) cyanide (557-21-1) + 3-iodo-pyridin-4-ol (89282-03-1) → 4-hydroxypyridine-3-carbonitrile (89324-16-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield: 53.0%

5-(dimethylamino)-2-[(dimethylamino)methylene]-3-oxopent-4-enenitrile (959972-32-8) → 4-hydroxypyridine-3-carbonitrile (89324-16-3)

Guidance literature:

With ammonium acetate; In ethanol; at 60 ℃; Heating / reflux;

Reference yield: 53.0%

5-(dimethylamino)-2-[(dimethylamino)methylene]-3-oxopent-4-enenitrile (959972-32-8) + ammonium acetate (631-61-8,92206-38-7) → 4-hydroxypyridine-3-carbonitrile (89324-16-3)

Guidance literature:

In ethanol; for 60h; Heating / reflux;

upstream raw materials:

5-(dimethylamino)-2-[(dimethylamino)methylene]-3-oxopent-4-enenitrile

ammonium acetate

zinc(II) cyanide

3-iodo-pyridin-4-ol

Downstream raw materials:

4-hydroxy-5-iodopyridine-3-carbonitrile

Refernces

• 1、 -. "5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS". Page/Page column 49. . Retrieved 2009/07/17.