CHEMBRDG-BB 4003866

Base Information

• Chemical Name: CHEMBRDG-BB 4003866
• CAS No.: 1015845-52-9
• Molecular Formula: C10H7FN2O
• Molecular Weight: 190.177
• Hs Code.: 2933199090
• Mol file: 1015845-52-9.mol

Synonyms:CHEMBRDG-BB 4003866;1-(2-Fluoro-phenyl)-1H-pyrazole-4-carbaldehyde;1-(2-FLUORO-PHENYL)PYRAZOLE-4-CARBOXALDEHYDE;UKRORGSYN-BB BBV-065905

Chemical Property of CHEMBRDG-BB 4003866

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Fluorophenyl)-1H-pyrazole-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMBRDG-BB 4003866

There total 2 articles about CHEMBRDG-BB 4003866 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

ortho-difluorobenzene (367-11-3) + 1H-pyrazole-4-carbaldehyde (35344-95-7) → 1-(2-fluorophenyl)-1H- pyrazole-4-carbaldehyde (1015845-52-9)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In acetonitrile; at 20 ℃; for 36h; Sealed tube; Inert atmosphere; Irradiation; Electrolysis;

DOI:10.1002/anie.201909983

Reference yield:

fluorobenzene (462-06-6) + 1H-pyrazole-4-carbaldehyde (35344-95-7) → 1-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde (890652-03-6) + 1-(3-fluorophenyl)-1H-pyrazole-4-carbaldehyde (936940-82-8) + 1-(2-fluorophenyl)-1H- pyrazole-4-carbaldehyde (1015845-52-9)

Guidance literature:

With C₂₄H₄₂N₃⁽¹⁺⁾*ClO₄^(1-); lithium perchlorate; acetic acid; In acetonitrile; at 20 ℃; for 60h; Overall yield = 36 percent; Overall yield = 27.4 mg; Electrochemical reaction; Sealed tube; Irradiation;

DOI:10.1002/anie.201906381

Reference yield: 99.0%

1-(2-fluorophenyl)-1H- pyrazole-4-carbaldehyde (1015845-52-9) → (1-(2-fluorophenyl)-1H-pyrazol-4-yl)methanol

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 2h;

upstream raw materials:

fluorobenzene

1H-pyrazole-4-carbaldehyde

ortho-difluorobenzene

Downstream raw materials:

4-(chloromethyl)-1-(2-fluorophenyl)-1H-pyrazole

Refernces

• 1、 Huang, He,Strater, Zack M.,Rauch, Michael,Shee, James,Sisto, Thomas J.,Nuckolls, Colin,Lambert, Tristan H.. "Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication". supporting information. p. 13318 - 13322. Retrieved 2019/08/12.