3-bromo-1H-pyrrolo[3,2-b]pyridine

Base Information

• Chemical Name: 3-bromo-1H-pyrrolo[3,2-b]pyridine
• CAS No.: 23688-47-3
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.03
• Hs Code.: 2933998090
• Mol file: 23688-47-3.mol

Synonyms:3-bromo-1H-pyrrolo[3,2-b]pyridine;3-BROMO-4-AZAINDOLE

Chemical Property of 3-bromo-1H-pyrrolo[3,2-b]pyridine

Chemical Property:

• Vapor Pressure: 0.000117mmHg at 25°C
• Melting Point: 232-238 °C
• Boiling Point: 346.3°C at 760 mmHg
• PKA: 12.99±0.40(Predicted)
• Flash Point: 163.2°C
• PSA: 28.68000
• Density: 1.77g/cm³
• LogP: 2.32540
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-1H-pyrrolo[3,2-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-bromo-1H-pyrrolo[3,2-b]pyridine

There total 2 articles about 3-bromo-1H-pyrrolo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1H-pyrrolo[3,2-b]pyridine (272-49-1) → 3-bromo-1H-pyrrolo[3,2-b]pyridine (23688-47-3)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Reference yield:

→ 3-bromo-1H-pyrrolo[3,2-b]pyridine (23688-47-3)

Guidance literature:

4-Azaindol, Brom;

DOI:10.1007/BF00475418

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-bromo-1H-pyrrolo[3,2-b]pyridine (23688-47-3) → tert-butyl 3-bromo-1H-pyrrolo[3,2-b]pyridine-1-carboxylate (192189-15-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

1H-pyrrolo[3,2-b]pyridine

Downstream raw materials:

tert-butyl 3-bromo-1H-pyrrolo[3,2-b]pyridine-1-carboxylate

3-bromo-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-pyrrolo[3,2-b]pyridine

4-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)aniline

1-methyl-3-(4-nitrophenyl)-1H-pyrrolo[3,2-b]pyridine

Refernces

• 1、 Jiang, Xuefeng,Li, Yiming,Lu, Lingling. "Visible-light-promoted oxidative halogenation of (hetero)arenes". supporting information. p. 5989 - 5994. Retrieved 2020/10/18.
• 2、 Das, Sanjib,Shelke, Dnyaneshwar E.,Harde, Rajendra L.,Avhad, Vijayshree B.,Khairatkar-Joshi, Neelima,Gullapalli, Srinivas,Gupta, Praveen K.,Gandhi, Maulik N.,Bhateja, Deepak K.,Bajpai, Malini,Joshi, Ashwini A.,Marathe, Megha Y.,Gudi, Girish S.,Jadhav, Satyawan B.,Mahat, Mahamad Yunnus A.,Thomas, Abraham. "Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part II". supporting information. p. 3238 - 3242. Retrieved 2014/07/22.