MK-5108 (VX-689)

Base Information

• Chemical Name: MK-5108 (VX-689)
• CAS No.: 1010085-13-8
• Molecular Formula: C22H21ClFN3O3S
• Molecular Weight: 461.94
• Mol file: 1010085-13-8.mol

Synonyms:(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexanecarboxylic acid;MK 5108;

Chemical Property of MK-5108 (VX-689)

Chemical Property:

• Boiling Point: 637.6±65.0 °C(Predicted)
• PKA: 4.41±0.44(Predicted)
• PSA: 112.58000
• Density: 1.429
• LogP: 5.78230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: ≥23.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

Purity/Quality:

98% min ^*data from raw suppliers

MK 5108 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: MK-5108 is a highly selective Aurora-A kinase inhibitor that shows antitumor activity alone and in combination with Docetaxel (D494420).