4-piperidin-3-ylaniline

Base Information

• Chemical Name: 4-piperidin-3-ylaniline
• CAS No.: 19733-56-3
• Molecular Formula: C11H16N2
• Molecular Weight: 176.261
• Hs Code.: 2933399090
• Mol file: 19733-56-3.mol

Synonyms:4-piperidin-3-ylaniline

Chemical Property of 4-piperidin-3-ylaniline

Chemical Property:

• Melting Point: 96-97 °C
• Boiling Point: 331.9±35.0 °C(Predicted)
• PKA: 10.26±0.10(Predicted)
• PSA: 38.05000
• Density: 1.043±0.06 g/cm3(Predicted)
• LogP: 2.64580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-(Piperidin-3-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Piperidin-3-yl)aniline is a reagent in the development of the fit-for-purpose large-scale synthesis of oral PARP inhibitor.

Technology Process of 4-piperidin-3-ylaniline

There total 19 articles about 4-piperidin-3-ylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-(4'-nitrophenyl)pyridine (4282-46-6) → 3-(4-aminophenyl)piperidine (19733-56-3)

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; hydrogen; In methanol; at 20 ℃; for 24h; under 2585.81 Torr;

DOI:10.1021/jm901188v

Reference yield: 96.0%

1-benzyl-3-(4-nitrophenyl)pyridinium bromide → 3-(4-aminophenyl)piperidine (19733-56-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; acetic acid; at 30 ℃; for 12h; under 1125.11 - 1500.15 Torr; Temperature; Pressure; Reagent/catalyst;

Reference yield: 96.0%

N-allyl-3-(4-nitrophenyl)pyridine quaternary ammonium salt → 3-(4-aminophenyl)piperidine (19733-56-3)

Guidance literature:

With sodium tetrahydroborate; zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 3.5h; Concentration; Temperature; Inert atmosphere;

upstream raw materials:

3-(4'-nitrophenyl)pyridine

3-pyridylboronic acid

para-nitrophenyl bromide

methyl (4-nitrophenyl)acetate

Downstream raw materials:

(3S)-3-(4-aminophenyl)piperidinium (2R,3R)-3-carboxy-2,3-dihydroxypropanoate

3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester

(3S)-3-[4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidinium chloride

(3S)-3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "Method for preparing 4-(piperidine-3-yl)aniline". Paragraph 0045; 0046. . Retrieved 2017/04/03.
• 2、 -. "A prepares Nepal to pull handkerchief Nepal method (by machine translation)". . . Retrieved 2017/07/23.