4-HYDROXY-7-NITROQUINOLINE

Base Information

• Chemical Name: 4-HYDROXY-7-NITROQUINOLINE
• CAS No.: 6270-14-0
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.158
• Hs Code.: 2933499090
• Mol file: 6270-14-0.mol

Synonyms:7-Nitroquinolin-4(1H)-one;

Chemical Property of 4-HYDROXY-7-NITROQUINOLINE

Chemical Property:

• Vapor Pressure: 2.58E-05mmHg at 25°C
• Melting Point: 314-317 °C (decomp)
• Refractive Index: 1.636
• Boiling Point: 358.3 °C at 760 mmHg
• PKA: 7.43±0.27(Predicted)
• Flash Point: 170.5 °C
• PSA: 78.94000
• Density: 1.419 g/cm³
• LogP: 2.37180

Purity/Quality:

98.5% ^*data from raw suppliers

4-hydroxy-7-nitroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-HYDROXY-7-NITROQUINOLINE

There total 12 articles about 4-HYDROXY-7-NITROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

4-hydroxy-7-nitroquinoline-3-carboxylic acid (40107-11-7) → 4-hydroxy-7-nitroquinoline (6270-14-0)

Guidance literature:

4-hydroxy-7-nitroquinoline-3-carboxylic acid; With ammonium hydroxide; silver nitrate; In water; for 0.5h; Heating;

In diphenylether; at 255 ℃; for 1h;

DOI:10.1021/jm9902180

Reference yield: 21.6%

2,2-dimethyl-5-((3-nitrophenylamino)methylene)-1,3-dioxane-4,6-dione (25063-48-3) → 5-nitroquinolin-4(1H)-one + 7-nitroquinolin-4(1H)-one (6270-14-0,75770-07-9)

Guidance literature:

at 600 ℃; under 0.01 Torr;

DOI:10.1055/s-2007-985573

Reference yield: 14.0%

C10H5N2O5(1-)*Ag(1+) (40107-12-8) → 4-hydroxy-7-nitroquinoline (6270-14-0)

Guidance literature:

In diphenylether; for 0.75h; Reflux;

DOI:10.1016/j.bmc.2013.04.040

upstream raw materials:

4-hydroxy-7-nitroquinoline-3-carboxylic acid

cycl-isopropylidene malonate

3-nitro-aniline

ethyl α-ethoxycarbonyl-β-(m-nitroanilino)acrylate

Downstream raw materials:

4-chloro-7-nitroquinoline

4-amino-7-nitroquinoline

4,7-diaminoquinoline

N-(7-nitroquinolin-4-yl)-N-[2-(N,N-dimethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

Refernces

• 1、 Darque, Albert,Dumetre, Aurelien,Hutter, Sebastien,Casano, Gilles,Robin, Maxime,Pannecouque, Christophe,Azas, Nadine. "Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates". supporting information; experimental part. p. 5962 - 5964. Retrieved 2010/06/17.
• 2、 Al-Awadi, Nouria A.,Abdelhamid, Ismail Abdelshafy,Al-Etaibi, Alya M.,Elnagdi, Mohamed Hilmy. "Gas-phase pyrolysis in organic synthesis: Rapid green synthesis of 4-quinolinones". . p. 2205 - 2208. Retrieved 2008/02/10.