(9S,13S,14S)-3-METHOXYMORPHINAN HYDROCHLORIDE

Base Information

• Chemical Name: (9S,13S,14S)-3-METHOXYMORPHINAN HYDROCHLORIDE
• CAS No.: 1087-69-0
• Molecular Formula: C17H23NO.ClH
• Molecular Weight: 0
• Hs Code.: 2925290090
• Mol file: 1087-69-0.mol

Synonyms:(9S,13S,14S)-3-METHOXYMORPHINAN HYDROCHLORIDE;N-NordextroMethorphan Hydrochloride

Chemical Property of (9S,13S,14S)-3-METHOXYMORPHINAN HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: White powder
• Melting Point: 247-249°C
• PSA: 21.26000
• LogP: 4.17200
• Storage Temp.: Refrigerator
• Solubility.: H2O: soluble10mg/mL, clear

Purity/Quality:

98%,99%, ^*data from raw suppliers

(+)-3-Methoxymorphinan hydrochloride analytical standard, for drug analysis ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite

Technology Process of (9S,13S,14S)-3-METHOXYMORPHINAN HYDROCHLORIDE

There total 1 articles about (9S,13S,14S)-3-METHOXYMORPHINAN HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dextromethorphan hydrobromide → (+)-3-methoxymorphinan hydrochloride (36397-14-5,1087-69-0)

Guidance literature:

With ammonium hydroxide; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; In 1,2-dichloro-ethane; for 6h; Heating;

DOI:10.1021/jm00100a019

Reference yield:

(+)-3-Methoxymorphinan hydrochloride (1087-69-0) → [2H]-Dextromethorphan 3,17-d6 (1079043-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 60 °C

1.2: 1.17 h / 70 °C / Reflux

2.1: acetic acid; hydrogen bromide / water / 1 h / 110 °C

3.1: sodium t-butanolate / N,N-dimethyl-formamide / 1 h / 10 - 20 °C

3.2: 8 h / 50 °C

3.3: 6 h / 50 °C

With hydrogen bromide; potassium carbonate; acetic acid; potassium iodide; sodium t-butanolate; In water; N,N-dimethyl-formamide;

Downstream raw materials:

[2H]-Dextromethorphan 3,17-d6

Refernces