6-O-alpha-D-Glucosyl-beta-cyclodextrin

Base Information

• Chemical Name: 6-O-alpha-D-Glucosyl-beta-cyclodextrin
• CAS No.: 92517-02-7
• Molecular Formula: C₄₈H₈₀O₄₀
• Molecular Weight: 1297.14
• Mol file: 92517-02-7.mol

Synonyms:mono-6-O-alpha-D-Glucosyl beta-cyclodextrin;beta-Cyclodextrin, O-alpha-D-glucopyranosyl-(1-6A)-;

Chemical Property of 6-O-alpha-D-Glucosyl-beta-cyclodextrin

Chemical Property:

• Refractive Index: 158 ° (C=1, H2O)
• PKA: 12.55±0.70(Predicted)
• PSA: 633.20000
• Density: 1.887 g/cm³
• LogP: -17.40640
• Storage Temp.: 2-8°C
• Solubility.: Water (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

6-O-α-D-Glucosyl-β-cyclodextrin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-O-α-D-Glucosyl-β-cyclodextrin is an additive to improve the solubility of quetiapine.

Technology Process of 6-O-alpha-D-Glucosyl-beta-cyclodextrin

There total 8 articles about 6-O-alpha-D-Glucosyl-beta-cyclodextrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

<2,3-di-O-acetyl-6-O-(α-D-glucopyranosyl)>hexakis(2,3,6-tri-O-acetyl)cyclomaltoheptaose (116525-08-7,116562-93-7) → 6-O-α-D-glucopyranosyl-β-cyclodextrin (92517-02-7,127181-68-4,142187-75-5,149496-53-7)

Guidance literature:

With sodium methylate; In methanol; for 2h;

DOI:10.1016/0008-6215(88)84140-5

Reference yield:

→ 61,64-di-O-(α-D-glucopyranosyl)-cyclomaltoheptaose (108202-93-3) + 6-O-α-D-Glucopyranosyl α-cyclodextrin (10058-19-2) + 6-O-α-D-glucopyranosyl-β-cyclodextrin (92517-02-7,127181-68-4,142187-75-5,149496-53-7) + alpha cyclodextrin (10016-20-3)

Guidance literature:

Multistep reaction. Further byproducts given; 1.) cyclomaltodextrin glucanotransferase enzyme, water, 55 deg C, 40 h, pH 7.6, 2.) 0.01 percent (w/v) glucoamylase GNL-2 enzyme, water, 40 deg C, 5 h;

DOI:10.1016/S0008-6215(00)90195-2

Reference yield:

D-Glucose (2280-44-6) + β‐cyclodextrin (7585-39-9) → 6-O-α-D-glucopyranosyl-β-cyclodextrin (92517-02-7,127181-68-4,142187-75-5,149496-53-7) + 6-O-α-D-glucosyl-β-cyclodextrine

Guidance literature:

With activated carbon; at 179.84 ℃; for 1h; Reagent/catalyst;

DOI:10.1007/s10847-021-01089-z

upstream raw materials:

maltosyl(α1->6)β-cyclodextrin

6-O-α-D-maltotriosyl-β-cyclodextrin

<2,3-di-O-acetyl-6-O-(α-D-glucopyranosyl)>hexakis(2,3,6-tri-O-acetyl)cyclomaltoheptaose

6-O-α-(6²-O-α-maltotriosyl)maltotriosyl-cG7

Refernces

• 1、 Fuegedi, Peter,Nanasi, Pal,Szejtli, Jozsef. "SYNTHESIS OF 6-O-α-D-GLUCOPYRANOSYLCYCLOMALTOHEPTAOSE". . p. 173 - 182. Retrieved 2007/10/02.
• 2、 Abe,Mizowaki,Hizukuri,Koizumi,Utamura. "Synthesis of branched cyclomalto-oligosaccharides using Pseudomonas isoamylase.". . p. 81 - 92. Retrieved 2007/10/02.