3,4-Difluoro-6-Nitroanisole

Base Information

• Chemical Name: 3,4-Difluoro-6-Nitroanisole
• CAS No.: 66684-64-8
• Molecular Formula: C7H5F2NO3
• Molecular Weight: 189.118
• Hs Code.: 2909309090
• Mol file: 66684-64-8.mol

Synonyms:1,2-Difluoro-4-methoxy-5-nitrobenzene;

Chemical Property of 3,4-Difluoro-6-Nitroanisole

Chemical Property:

• Vapor Pressure: 0.0156mmHg at 25°C
• Refractive Index: 1.502
• Boiling Point: 264.7 °C at 760 mmHg
• Flash Point: 113.9 °C
• PSA: 55.05000
• Density: 1.414 g/cm³
• LogP: 2.40480
• Storage Temp.: 2-8°C

Purity/Quality:

95-99% ^*data from raw suppliers

1,2-difluoro-4-methoxy-5-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Difluoro-6-Nitroanisole

There total 2 articles about 3,4-Difluoro-6-Nitroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4,5-difluoro-2-nitro-phenol (55346-97-9) + methyl iodide (74-88-4) → 1,2-difluoro-4-methoxy-5-nitro-benzene (66684-64-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

3,4-difluorophenol (2713-33-9) → 1,2-difluoro-4-methoxy-5-nitro-benzene (66684-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; tetrabutylammomium bromide / 1,1-dichloroethane / 14.75 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With tetrabutylammomium bromide; nitric acid; potassium carbonate; In 1,1-dichloroethane; N,N-dimethyl-formamide;

Reference yield: 95.0%

1,2-difluoro-4-methoxy-5-nitro-benzene (66684-64-8) → 1,2-difluoro-4-methoxy-5-nitrobenzene (1017779-71-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 2h;

upstream raw materials:

4,5-difluoro-2-nitro-phenol

methyl iodide

3,4-difluorophenol

Downstream raw materials:

1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

5-Fluoro-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

(2-fluoro-5-methoxy-4-nitrophenyl)(methyl)sulfane

1,2-difluoro-4-methoxy-5-nitrobenzene

Refernces

• 1、 -. "FURTHER SUBSTITUTED TRIAZOLO QUINOXALINE DERIVATIVES". Paragraph 0440-0442. . Retrieved 2020/02/08.