WYE-687

Base Information

• Chemical Name: WYE-687
• CAS No.: 1062161-90-3
• Molecular Formula: C28H32N8O3
• Molecular Weight: 528.614
• Mol file: 1062161-90-3.mol

Synonyms:WYE-687;N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester;methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenylcarbamate

Chemical Property of WYE-687

Chemical Property:

• PKA: 13.42±0.70(Predicted)
• PSA: 110.53000
• Density: 1.40
• LogP: 3.81620
• Solubility.: insoluble in H2O; insoluble in EtOH; insoluble in DMSO

Purity/Quality:

98%Min ^*data from raw suppliers

WYE-687 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to m TorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer. WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer.

Technology Process of WYE-687

There total 2 articles about WYE-687 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + bis(trichloromethyl) carbonate (32315-10-9) + 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)aniline hydrochloride (1198178-29-8) → WYE-687 (1062161-90-3)

Guidance literature:

bis(trichloromethyl) carbonate; 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)aniline hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

methanol; In dichloromethane; at 20 ℃;

DOI:10.1021/jm900851f

Reference yield:

→ WYE-687 (1062161-90-3)

Guidance literature:

Reference yield:

WYE-687 (1062161-90-3) → WYE-687 hydrochloride (1198178-23-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm900851f

upstream raw materials:

methanol

bis(trichloromethyl) carbonate

4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)aniline hydrochloride

Downstream raw materials:

WYE-687 hydrochloride

Refernces

• 1、 -. "PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS". Page/Page column 103. . Retrieved 2008/12/08.