Indacaterol Maleate

Base Information Edit

Chemical Name:Indacaterol Maleate
CAS No.:753498-25-8
Deprecated CAS:435273-74-8
Molecular Formula:C₄H₄O₄*C₂₄H₂₈N₂O₃
Molecular Weight:508.571
Hs Code.:29339900
European Community (EC) Number:610-125-8
UNII:2JEC1ITX7R
Wikidata:Q27137018
NCI Thesaurus Code:C81640
ChEMBL ID:CHEMBL1789842
Mol file:753498-25-8.mol

Synonyms:Indacaterol maleate

Suppliers and Price of Indacaterol Maleate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
IndacaterolMaleicAcidSalt
5mg
$ 275.00

TRC
IndacaterolMaleicAcidSalt
1mg
$ 120.00

TCI Chemical
Indacaterol Maleate >98.0%(HPLC)
20mg
$ 119.00

TCI Chemical
Indacaterol Maleate >98.0%(HPLC)
100mg
$ 412.00

Medical Isotopes, Inc.
IndacaterolMaleicAcidSalt
5 mg
$ 890.00

Matrix Scientific
Indacaterol Maleate 95+%
1g
$ 3036.00

DC Chemicals
Indacaterol Maleate 99%
1 g
$ 1200.00

DC Chemicals
Indacaterol Maleate 99%
250 mg
$ 600.00

Crysdot
Indacaterol Maleate 98+%
50mg
$ 59.00

Crysdot
Indacaterol Maleate 98+%
25mg
$ 40.00

Total 78 raw suppliers

Chemical Property of Indacaterol Maleate Edit

Chemical Property:

Appearance/Colour:White Solid
Melting Point:195-197°C (dec.)
PSA：160.21000
LogP:3.66390
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:508.22095136
Heavy Atom Count:37
Complexity:708

Purity/Quality:

98%,99%, ^*data from raw suppliers

IndacaterolMaleicAcidSalt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=C(C=C2CC(CC2=C1)NCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=CC(=O)O)C(=O)O
Isomeric SMILES:CCC1=C(C=C2CC(CC2=C1)NC[C@@H](C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=C\C(=O)O)\C(=O)O
Recent ClinicalTrials:Pharmacodynamics, Safety, Tolerability, and Pharmacokinetics of Two Orally Inhaled Indacaterol Salts in Adult Subjects With Asthma.
Recent EU Clinical Trials:Comparison of 1-year treatment with inhaled long acting bronchodilators (LABD) plus inhaled glucocorticosteroids (ICS) versus LABD without ICS on re-hospitalizations and/or death in elderly patients with chronic obstructive pulmonary disease (COPD) recently hospitalized because of an acute exacerbation of COPD (ICS-Life study).
Recent NIPH Clinical Trials:Safety of LAMA/LABA combination therapy in the COPD patients
Uses A long-acting β2 adrenoreceptor agonist and bronchodilator, for the treatment of asthma and chronic obstructive pulmonary disease.
Clinical Use Indacaterol is a b-adrenoceptor agonist currently approved in Europe as Onbrez, and is marketed by Novartis. It needs to be taken only once a day, unlike competitors formoterol and salmeterol. These drugs are used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. Onbrez is administered via an aerosol formulation through a dry powder inhaler. A Phase III trial published in July 2010 suggested that indacaterol is significantly more effective than twice-daily formoterol in improving FEV1 and reduces the need for rescue medication.

Technology Process of Indacaterol Maleate

There total 42 articles about Indacaterol Maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%