2-Phenyl-1-pyridin-3-yl-ethylamine

Base Information

• Chemical Name: 2-Phenyl-1-pyridin-3-yl-ethylamine
• CAS No.: 118385-85-6
• Molecular Formula: C13H14N2
• Molecular Weight: 198
• Mol file: 118385-85-6.mol

Synonyms:benzylpyridin-3-ylmethylamine;2-Phenyl-1-[3]pyridyl-aethylamin;2-Phenyl-1-pyridin-3-yl-ethylamine;2-phenyl-1-[3]pyridyl-ethylamine;

Chemical Property of 2-Phenyl-1-pyridin-3-yl-ethylamine

Chemical Property:

• Boiling Point: None °C
• PSA: 38.91000
• LogP: 3.02440

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenyl-1-pyridin-3-yl-ethylamine

There total 7 articles about 2-Phenyl-1-pyridin-3-yl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-pyridinecarboxaldehyde (500-22-1) + toluene (108-88-3,15644-74-3,16713-13-6) → 1-(3-pyridinyl)-2-phenylethylamine (118385-85-6)

Guidance literature:

With caesium carbonate; lithium hexamethyldisilazane; at 110 ℃; for 12h; chemoselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02737

Reference yield:

2-phenyl-1-[3]pyridyl-ethanone oxime (42899-45-6,110169-14-7) → 1-(3-pyridinyl)-2-phenylethylamine (118385-85-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 2585.7 Torr; Yield given;

DOI:10.1021/jm00010a004

Reference yield:

3-pyridinecarboxylic acid ethyl ester (614-18-6) → 1-(3-pyridinyl)-2-phenylethylamine (118385-85-6)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanolic sodium ethylate

2: hydrobromic acid; water

3: 160 - 170 °C / Erwaermen des Reaktionsprodukts mit wss. HCl

With water; hydrogen bromide; sodium ethanolate;

DOI:10.1021/ja01161a031

upstream raw materials:

2-phenyl-1-(pyridin-3-yl)ethanone

ammonium formate

2-phenyl-1-[3]pyridyl-ethanone oxime

3-pyridinecarboxylic acid ethyl ester

Refernces

• 1、 -. "Anthranilamides and methods of their use". . . Retrieved 2008/06/13.
• 2、 -. "Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties". . . Retrieved 2008/06/13.