4-(4-CHLORO-2-NITROPHENYL)MORPHOLINE

Base Information

• Chemical Name: 4-(4-CHLORO-2-NITROPHENYL)MORPHOLINE
• CAS No.: 65976-60-5
• Molecular Formula: C10H11ClN2O3
• Molecular Weight: 242.662
• Hs Code.: 2934999090
• Mol file: 65976-60-5.mol

Synonyms:BUTTPARK 45\09-19;4-(2-Nitro-4-chlorophenyl)morpholine;2-Morpholino-5-chloro-1-nitrobenzene;1-Morpholino-2-nitro-4-chlorobenzene;

Chemical Property of 4-(4-CHLORO-2-NITROPHENYL)MORPHOLINE

Chemical Property:

• PSA: 58.29000
• LogP: 2.67300

Purity/Quality:

4-(4-Chloro-2-nitrophenyl)morpholine, 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-CHLORO-2-NITROPHENYL)MORPHOLINE

There total 4 articles about 4-(4-CHLORO-2-NITROPHENYL)MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 2,5-dichloronitrobenzene (89-61-2) → 4-(4-chloro-2-nitro-phenyl)morpholine (65976-60-5)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 20h; under 4500360 Torr;

DOI:10.1246/bcsj.64.42

Reference yield: 81.0%

morpholine (110-91-8,99108-56-2) + potassium 2-nitro-4-chlorobenzoate (1448355-81-4) → 4-(4-chloro-2-nitro-phenyl)morpholine (65976-60-5)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; tetraammine palladium hydrogen carbonate; In N,N-dimethyl acetamide; at 145 ℃; for 16h; Sealed tube;

DOI:10.1002/anie.201812068

Reference yield:

morpholine (110-91-8,99108-56-2) + 2-fluoro-5-chloronitrobenzene (345-18-6) → 4-(4-chloro-2-nitro-phenyl)morpholine (65976-60-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 4h;

DOI:10.1016/j.bioorg.2021.105244

upstream raw materials:

morpholine

2,5-dichloronitrobenzene

potassium 2-nitro-4-chlorobenzoate

2-fluoro-5-chloronitrobenzene

Downstream raw materials:

5-chloro-2-morpholinoaniline

Refernces

• 1、 Pichette Drapeau, Martin,Bahri, Janet,Lichte, Dominik,Goo?en, Lukas J.. "Decarboxylative ipso Amination of Activated Benzoic Acids". supporting information. p. 892 - 896. Retrieved 2019/01/04.
• 2、 Ibata, Toshikazu,Isogami, Yasushi,Toyoda, Jiro. "Aromatic Nucleophilic Substitution of Halobenzenes with Amines under High Pressure". . p. 42 - 49. Retrieved 2007/10/02.