(2-(Methylthio)pyriMidin-4-yl)Methanol

Base Information

• Chemical Name: (2-(Methylthio)pyriMidin-4-yl)Methanol
• CAS No.: 102921-92-6
• Molecular Formula: C6H8N2OS
• Molecular Weight: 156.208
• Hs Code.: 2933599590
• Mol file: 102921-92-6.mol

Synonyms:(2-methylsulfanylpyrimidin-4-yl)methanol;(2-methylsulfanyl-pyrimidin-4-yl)-methanol;[2-(methylthio)pyrimidin-4-yl]-methanol;4-hydroxymethyl-2-methylthiopyrimidine;[2-(methylthio)pyrimidin-4-yl]methanol;(2-(methylthio)pyrimidin-4-yl)methanol;

Chemical Property of (2-(Methylthio)pyriMidin-4-yl)Methanol

Chemical Property:

• Boiling Point: 322.8±17.0 °C(Predicted)
• PKA: 13.19±0.10(Predicted)
• PSA: 71.31000
• Density: 1.30±0.1 g/cm3(Predicted)
• LogP: 0.69080
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(2-(Methylthio)pyrimidin-4-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-(Methylthio)pyriMidin-4-yl)Methanol

There total 10 articles about (2-(Methylthio)pyriMidin-4-yl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-tert-butyldiphenylsilyloxymethyl-2-methylthiopyrimidine (123061-69-8) → 4-(hydroxymethyl)-2-(methylthio)pyrimidine (102921-92-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/0040-4020(89)80011-0

Reference yield: 78.0%

4-tert-butyldimethylsilyloxymethyl-2-methylthiopyrimidine (123061-67-6) → 4-(hydroxymethyl)-2-(methylthio)pyrimidine (102921-92-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/0040-4020(89)80011-0

Reference yield: 68.0%

2-methylsulfanylpyrimidine-4-carboxylic acid (1126-44-9) → 4-(hydroxymethyl)-2-(methylthio)pyrimidine (102921-92-6)

Guidance literature:

With sodium tetrahydroborate; N,N-dimethylchloromethyleniminium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; at -78 - -20 ℃; for 3h;

DOI:10.1021/jm00158a009

upstream raw materials:

2-methylsulfanylpyrimidine-4-carboxylic acid

4-tert-butyldimethylsilyloxymethyl-2-methylthiopyrimidine

2-methylthio-4-thexyldimethylsilyloxymethylpyrimidine

4-tert-butyldiphenylsilyloxymethyl-2-methylthiopyrimidine

Downstream raw materials:

4-(chloromethyl)-2-methylsulfanylpyrimidine

Refernces

• 1、 -. "Macrocyclic MCL-1 inhibitors and methods of use". Paragraph 0565. . Retrieved 2019/02/28.
• 2、 -. "Novel Cyclic Urea Derivatives, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors". Page/Page column 19. . Retrieved 2009/04/24.