Technology Process of 6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]iMidazol-7-yl)-N-Methyl-2-naphthaMide
There total 25 articles about 6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]iMidazol-7-yl)-N-Methyl-2-naphthaMide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-[1,3-dihydroxy-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-methyl-2-naphthamide;
With
methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; water; dimethyl sulfoxide;
at 0 - 8 ℃;
for 1.5h;
With
N-ethyl-N,N-diisopropylamine;
In
methanol; acetonitrile;
at 60 - 63 ℃;
for 2.33333h;
With
ammonium chloride;
In
methanol; water; ethyl acetate; acetonitrile;
at 25 ℃;
- Guidance literature:
-
methylamine;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.833333h;
Inert atmosphere;
6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N,N-diisopropyl-2-naphthamide;
In
tetrahydrofuran; hexane;
at 0 - 20 ℃;
for 16h;
Inert atmosphere;
With
water; sodium chloride;
In
tetrahydrofuran; hexane;
Inert atmosphere;
DOI:10.1016/j.bmc.2011.08.068
- Guidance literature:
-
6-[(1S)-1,3-dihydroxy-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-methyl-2-naphthamide;
With
methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 0 - 5 ℃;
for 0.666667h;
In
tetrahydrofuran; methanol; acetonitrile;
at 60 - 65 ℃;
for 4h;
With
hydrogenchloride; sodium hydroxide; ammonium chloride;
In
tetrahydrofuran; methanol; water; acetonitrile;
at 0 - 5 ℃;
pH=8;
