4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine

Base Information

• Chemical Name: 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine
• CAS No.: 1007206-27-0
• Molecular Formula: C10H12Cl3N3O
• Molecular Weight: 296.584
• Hs Code.: 2934999090
• Mol file: 1007206-27-0.mol

Synonyms:4-[4,6-Dichloro-5-(2-chloroethyl)pyrimidin-2-yl]morpholine;

Chemical Property of 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine

Chemical Property:

• PSA: 38.25000
• LogP: 2.46630
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(4,6-Dichloro-5-(2-chloroethyl)pyrimidin-2-yl)morpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine

There total 6 articles about 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-(2-hydroxyethyl)-2-morpholin-4-yl-pyrimidine-4,6-diol (1178564-17-4) → 4-[4,6-dichloro-5-(2-chloroethyl)-pyrimidin-2-yl]-morpholine (1007206-27-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In water; toluene; at 0 - 100 ℃; for 7h;

Reference yield: 28.0%

2-oxotetrahydrofuran-3-carboxylic acid methyl ester (127915-15-5,19406-00-9) + morpholinoformamidine hydrochloride (5638-78-8) → 4-[4,6-dichloro-5-(2-chloroethyl)-pyrimidin-2-yl]-morpholine (1007206-27-0)

Guidance literature:

2-oxotetrahydrofuran-3-carboxylic acid methyl ester; morpholinoformamidine hydrochloride; With methanol; sodium; for 2h; Heating / reflux;

With trichlorophosphate; at 100 ℃; for 10h;

With sodium hydroxide; water; at 0 ℃;

Reference yield: 23.0%

2-oxotetrahydrofuran-3-carboxylic acid methyl ester (127915-15-5,19406-00-9) + morpholine-4-carboximidamide hydrochloride → 4-[4,6-dichloro-5-(2-chloroethyl)-pyrimidin-2-yl]-morpholine (1007206-27-0)

Guidance literature:

2-oxotetrahydrofuran-3-carboxylic acid methyl ester; morpholine-4-carboximidamide hydrochloride; With sodium methylate; In methanol; for 2h; Reflux;

With trichlorophosphate; In methanol; at 100 ℃;

upstream raw materials:

2-oxotetrahydrofuran-3-carboxylic acid methyl ester

morpholinoformamidine hydrochloride

5-(2-hydroxyethyl)-2-morpholin-4-yl-pyrimidine-4,6-diol

Morpholine-4-carboxamidine; hydrobromide

Downstream raw materials:

6-chloro-5-(2-chloroethyl)-N-[(4-methoxyphenyl)methyl]-2-morpholinopyrimidin-4-amine

4-chloro-7-methanesulfonyl-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

4-(4-chloro-7-(pyridin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl)morpholine

CH5132799

Refernces

• 1、 Kawada, Hatsuo,Ebiike, Hirosato,Tsukazaki, Masao,Yamamoto, Shun,Koyama, Kohei,Nakamura, Mitsuaki,Morikami, Kenji,Yoshinari, Kiyoshi,Yoshida, Miyuki,Ogawa, Kotaro,Shinma, Nobuo,Tsukuda, Takuo,Ohwada, Jun. "Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability". . p. 7650 - 7660. Retrieved 2015/12/18.
• 2、 Ohwada, Jun,Ebiike, Hirosato,Kawada, Hatsuo,Tsukazaki, Masao,Nakamura, Mitsuaki,Miyazaki, Takuya,Morikami, Kenji,Yoshinari, Kiyoshi,Yoshida, Miyuki,Kondoh, Osamu,Kuramoto, Shino,Ogawa, Kotaro,Aoki, Yuko,Shimma, Nobuo. "Discovery and biological activity of a novel class i PI3K inhibitor, CH5132799". scheme or table. p. 1767 - 1772. Retrieved 2011/05/05.