Avibactam

Base Information Edit

Chemical Name:Avibactam
CAS No.:1192500-31-4
Deprecated CAS:794508-22-8
Molecular Formula:C7H11N3O6S
Molecular Weight:265.247
Hs Code.:
UNII:7352665165,06MFO7817I
DSSTox Substance ID:DTXSID901026066
Nikkaji Number:J3.098.586I
Wikipedia:Avibactam
Wikidata:Q15410251
NCI Thesaurus Code:C171777
RXCUI:1603834
ChEMBL ID:CHEMBL1689063
Mol file:1192500-31-4.mol

Synonyms:avibactam;NXL 104;NXL-104;NXL104

Suppliers and Price of Avibactam

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Avibactamfreeacid 98+%
5mg
$ 168.00

Crysdot
Avibactamfreeacid 98+%
50mg
$ 1050.00

Crysdot
Avibactamfreeacid 98+%
10mg
$ 315.00

Chemenu
(1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-ylhydrogensulfate 98%
10mg
$ 295.00

Chemenu
(1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-ylhydrogensulfate 98%
50mg
$ 982.00

ApexBio Technology
Avibactam
5mg
$ 537.00

American Custom Chemicals Corporation
AVIBACTAM 95.00%
100MG
$ 995.00

American Custom Chemicals Corporation
AVIBACTAM 95.00%
5MG
$ 499.80

Total 71 raw suppliers

Chemical Property of Avibactam Edit

Chemical Property:

PKA:-4.59±0.18(Predicted)
PSA：139.61000
Density:1.85
LogP:0.58100
XLogP3:-1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:265.03685625
Heavy Atom Count:17
Complexity:457

Purity/Quality:

99% ^*data from raw suppliers

Avibactamfreeacid 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(N2CC1N(C2=O)OS(=O)(=O)O)C(=O)N
Isomeric SMILES:C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)O)C(=O)N
Recent ClinicalTrials:To Investigate the Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI)
Recent EU Clinical Trials:A PROSPECTIVE, RANDOMIZED, OPEN-LABEL, COMPARATIVE STUDY TO ASSESS THE EFFICACY, SAFETY AND TOLERABILITY OF AZTREONAM-AVIBACTAM (ATM-AVI) AND BEST AVAILABLE THERAPY FOR THE TREATMENT OF SERIOUS INFECTIONS DUE TO MULTI-DRUG RESISTANT GRAM- NEGATIVE BACTERIA PRODUCING METALLO-Β-LACTAMASE (MBL)

Technology Process of Avibactam

There total 36 articles about Avibactam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1383814-64-9
(2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

: 1192500-31-4
(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Guidance literature:: With chlorosulfonic acid; In N,N-dimethyl-formamide; at 30 ℃; for 48h; Reagent/catalyst;

Reference yield:

: 1192651-49-2
(1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

: 1192500-31-4
(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Guidance literature:: (1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; With hydrogen; 5% Pd-C; In dichloromethane; N,N-dimethyl-formamide; under 2250.23 Torr;

With sulfur trioxide-N,N-dimethylformamide complex; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: avibactam tetrabutylammonium salt

: 1192500-31-4
(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 0 - 5 ℃; for 0.5h; Solvent; Reagent/catalyst; Temperature; Concentration;