2-morpholino-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine

Base Information

• Chemical Name: 2-morpholino-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine
• CAS No.: 1192570-20-9
• Molecular Formula: C11H15F3N4O
• Molecular Weight: 276.2582096
• Hs Code.: 2934999090
• Mol file: 1192570-20-9.mol

Synonyms:2-morpholino-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine;beta-[2-(Trifluoromethyl)-5-pyrimidinyl]-4-morpholineethanamine

Chemical Property of 2-morpholino-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine

Chemical Property:

• PSA: 64.27000
• Density: 1.329±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 1.46560
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Morpholino-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-morpholino-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine

There total 4 articles about 2-morpholino-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

morpholin-4-yl-(2-trifluoromethyl-pyrimidin-5-yl)-acetonitrile (1192570-41-4) → 2-morpholin-4-yl-2-(2-trifluoromethyl-pyrimidin-5-yl)-ethylamine (1192570-20-9)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; at 20 ℃; for 0.416667h; under 1551.49 Torr; Inert atmosphere;

Reference yield:

ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate (304693-64-9) → 2-morpholin-4-yl-2-(2-trifluoromethyl-pyrimidin-5-yl)-ethylamine (1192570-20-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: DIBAL-h / toluene; dichloromethane / 3 h / -78 °C

1.2: 20 °C

2.1: sodium acetate / acetic acid / 20 °C

3.1: ammonium hydroxide; hydrogen / methanol / 0.42 h / 20 °C / 1551.49 Torr / Inert atmosphere

With ammonium hydroxide; hydrogen; sodium acetate; DIBAL-h; In methanol; dichloromethane; acetic acid; toluene;

Reference yield:

2-trifluoromethyl-5-pyrimidinecarboxaldehyde (304693-66-1) → 2-morpholin-4-yl-2-(2-trifluoromethyl-pyrimidin-5-yl)-ethylamine (1192570-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / acetic acid / 20 °C

2: ammonium hydroxide; hydrogen / methanol / 0.42 h / 20 °C / 1551.49 Torr / Inert atmosphere

With ammonium hydroxide; hydrogen; sodium acetate; In methanol; acetic acid;

upstream raw materials:

morpholin-4-yl-(2-trifluoromethyl-pyrimidin-5-yl)-acetonitrile

ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate

2-trifluoromethyl-5-pyrimidinecarboxaldehyde

Refernces

• 1、 -. "HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS". Page/Page column 48-49. . Retrieved 2014/08/07.