METHYL 4-BROMO-2-THIAZOLE CARBOXYLATE

Base Information

• Chemical Name: METHYL 4-BROMO-2-THIAZOLE CARBOXYLATE
• CAS No.: 1025468-06-7
• Molecular Formula: C5H4BrNO2S
• Molecular Weight: 222.06
• Hs Code.: 2934100090
• Mol file: 1025468-06-7.mol

Synonyms:Methyl 4-bromothiazole-2-carboxylate;

Chemical Property of METHYL 4-BROMO-2-THIAZOLE CARBOXYLATE

Chemical Property:

• Boiling Point: 277.0±32.0 °C(Predicted)
• PKA: -2.48±0.10(Predicted)
• PSA: 67.43000
• Density: 1.759±0.06 g/cm3(Predicted)
• LogP: 1.69220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl4-Bromo-2-thiazole-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-BROMO-2-THIAZOLE CARBOXYLATE

There total 2 articles about METHYL 4-BROMO-2-THIAZOLE CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 2,4-dibromo-1,3-thiazole (4175-77-3) → methyl 4-bromo-1,3-thiazole-2-carboxylate (1025468-06-7)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 3h; Sealed tube;

Reference yield:

methanol (67-56-1) + 4-bromo-1,3-thiazole-2-carboxylic acid (88982-82-5) → methyl 4-bromo-1,3-thiazole-2-carboxylate (1025468-06-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; at 20 ℃; for 17h;

Reference yield:

methyl 4-bromo-1,3-thiazole-2-carboxylate (1025468-06-7) + 4-methoxy-2-methylphenyl boronic acid (208399-66-0) → C13H13NO3S

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride; In methanol; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/ml4004815

upstream raw materials:

methanol

4-bromo-1,3-thiazole-2-carboxylic acid

carbon monoxide

2,4-dibromo-1,3-thiazole

Refernces

• 1、 -. "HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS". Page/Page column 36. . Retrieved 2008/12/05.