3,5-Dichloro-2-methoxypyridine

Base Information

• Chemical Name: 3,5-Dichloro-2-methoxypyridine
• CAS No.: 13472-58-7
• Molecular Formula: C6H5Cl2NO
• Molecular Weight: 178.02
• Hs Code.: 2933399090
• Mol file: 13472-58-7.mol

Synonyms:3,5-dichloro-2-methoxypyridine;

Chemical Property of 3,5-Dichloro-2-methoxypyridine

Chemical Property:

• Melting Point: 90℃
• Boiling Point: 200℃
• Flash Point: 75℃
• PSA: 22.12000
• Density: 1.363
• LogP: 2.39700
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Dichloro-2-methoxypyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-Dichloro-2-methoxypyridine

There total 2 articles about 3,5-Dichloro-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,3,5-trichloropyridine (16063-70-0) + sodium methylate (124-41-4) → 3,5-dichloro-2-methoxypyridine (13472-58-7)

Guidance literature:

In methanol; for 6h; Molecular sieve; Reflux;

DOI:10.1002/chem.202004311

Reference yield:

→ 3,5-dichloro-2-methoxypyridine (13472-58-7)

Guidance literature:

2,3,5-Trichlorpyridin, Natriummethylat, in Me.;

DOI:10.1039/j29660000991

Reference yield: 47.0%

3,5-dichloro-2-methoxypyridine (13472-58-7) + benzyl(bromo)zinc (62673-31-8) → 3-benzyl-5-chloro-2-methoxypyridine

Guidance literature:

With palladium diacetate; XPhos; In tetrahydrofuran; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1002/chem.202004311

upstream raw materials:

2,3,5-trichloropyridine

sodium methylate

Refernces