3-(4-Fluoro-phenyl)-2-methyl-acrylic acid

Base Information

• Chemical Name: 3-(4-Fluoro-phenyl)-2-methyl-acrylic acid
• CAS No.: 22138-72-3
• Molecular Formula: C10H9FO2
• Molecular Weight: 180.179
• Hs Code.: 2916399090
• Mol file: 22138-72-3.mol

Synonyms:3-(4-Fluoro-phenyl)-2-methyl-acrylic acid

Chemical Property of 3-(4-Fluoro-phenyl)-2-methyl-acrylic acid

Chemical Property:

• Melting Point: 151-153 °C
• Boiling Point: 287.2±15.0 °C(Predicted)
• PKA: 4.85±0.10(Predicted)
• PSA: 37.30000
• Density: 1.237±0.06 g/cm3(Predicted)
• LogP: 2.31360

Purity/Quality:

99.00% ^*data from raw suppliers

(2E)-3-(4-fluorophenyl)-2-methylprop-2-enoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Fluoro-phenyl)-2-methyl-acrylic acid

There total 9 articles about 3-(4-Fluoro-phenyl)-2-methyl-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 3-(4-fluorophenyl)-2-methyl-2-propenoate (134294-41-0) → (E)-3-(4-fluorophenyl)-2-methylacrylic acid (22138-72-3)

Guidance literature:

With water; potassium hydroxide; In ethanol; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.0c02894

Reference yield: 89.0%

aq LiOH + ethyl 3-(4-fluorophenyl)-2-methyl-2-propenoate (134294-41-0) → (E)-3-(4-fluorophenyl)-2-methylacrylic acid (22138-72-3)

Guidance literature:

In tetrahydrofuran;

Reference yield: 83.0%

4-fluorobenzaldehyde (459-57-4) + propionic acid anhydride (123-62-6) → 3-(4-fluorophenyl)-2-methylacrylic acid (22138-72-3)

Guidance literature:

propionic acid anhydride; With potassium carbonate; at 0 ℃; for 0.0833333h;

4-fluorobenzaldehyde; at 160 - 180 ℃; for 12h;

DOI:10.1016/j.ejmech.2013.01.012

upstream raw materials:

methyl-propanedioic acid

4-fluorobenzaldehyde

propionic acid anhydride

ethyl 3-(4-fluorophenyl)-2-methyl-2-propenoate

Downstream raw materials:

3-(4-fluorophenyl)-2-methylpropanoic acid

C₂₅H₂₇FO₂

Refernces

• 1、 Chen, Kai-Hong,He, Liang-Nian,Qiu, Li-Qi,Xia, Shu-Mei,Yang, Zhi-Wen,Yao, Xiang-Yang. "The synergistic copper/ppm Pd-catalyzed hydrocarboxylation of alkynes with formic acid as a CO surrogate as well as a hydrogen source: An alternative indirect utilization of CO2". supporting information. p. 8089 - 8095. Retrieved 2021/11/01.
• 2、 -. "COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING CANCER". Paragraph 0226. . Retrieved 2017/07/06.