Technology Process of Nimesulide
There total 8 articles about Nimesulide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water;
pH=~ 2;
- Guidance literature:
-
1-amino-2-phenoxy-4-nitrobenzene; methanesulfonyl chloride;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 23h;
Cooling with ice;
With
sodium hydroxide;
In
water;
for 16h;
Reflux;
DOI:10.1016/j.bmc.2015.10.007
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid / Reflux
2.1: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / 72 h / 20 °C / Molecular sieve
3.1: hydrazine hydrate / methanol / 6 h / Reflux
4.1: triethylamine / dichloromethane / 23 h / 20 °C / Cooling with ice
4.2: 16 h / Reflux
With
pyridine; pyridine N-oxide; oxygen; copper diacetate; hydrazine hydrate; acetic acid; triethylamine;
In
methanol; dichloromethane;
DOI:10.1016/j.bmc.2015.10.007