2-Chloro-5-fluoro-3-nitro-4-pyridinaMine

Base Information

• Chemical Name: 2-Chloro-5-fluoro-3-nitro-4-pyridinaMine
• CAS No.: 405230-90-2
• Molecular Formula: C5H3ClFN3O2
• Molecular Weight: 191.549
• Hs Code.: 2933399090
• Mol file: 405230-90-2.mol

Synonyms:QC-63;;4-amino-2-chloro-5-fluoro-3-nitropyridine;;

Chemical Property of 2-Chloro-5-fluoro-3-nitro-4-pyridinaMine

Chemical Property:

• PSA: 102.89000
• LogP: 2.05370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-chloro-5-fluoro-3-nitropyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-fluoro-3-nitro-4-pyridinaMine

There total 6 articles about 2-Chloro-5-fluoro-3-nitro-4-pyridinaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-5-fluoro-4-nitraminopyridine (405230-86-6) → 4-amino-2-chloro-5-fluoro-3-nitropyridine (405230-90-2)

Guidance literature:

With sulfuric acid; at 20 ℃;

DOI:10.1081/NCN-100108327

Reference yield: 90.0%

→ 4-amino-2-chloro-5-fluoro-3-nitropyridine (405230-90-2)

Guidance literature:

Reference yield:

4-amino-2-chloro-5-fluoropyridine (89510-90-7) → 4-amino-2-chloro-5-fluoro-3-nitropyridine (405230-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / conc. H₂SO₄; KNO₃ / 0 - 20 °C

2: 90 percent / conc. H₂SO₄ / 20 °C

With sulfuric acid; potassium nitrate;

DOI:10.1081/NCN-100108327

upstream raw materials:

2-chloro-5-fluoro-4-nitraminopyridine

2-chloro-5-fluoropyridine

2-chloro-5-fluoropyridine-1-oxide

4-amino-2-chloro-5-fluoropyridine

Downstream raw materials:

2-chloro-3,4-diamino-5-fluoropyridine

4-bromo-2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridine

4-chloro-7-fluoro-2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridine

N-(2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-yl)cyclopropanecarboxamide

Refernces

• 1、 -. "IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE". . . Retrieved 2011/10/10.
• 2、 Liu,Luo,Mozdziesz,Lin,Dutschman,Gullen,Cheng,Sartorelli. "Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents". . p. 1975 - 2000. Retrieved 2007/10/03.