4-Pyridinecarboxylicacid,3-ethyl-(9CI)

Base Information

• Chemical Name: 4-Pyridinecarboxylicacid,3-ethyl-(9CI)
• CAS No.: 4080-54-0
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.165
• Hs Code.: 2933399090
• Mol file: 4080-54-0.mol

Synonyms:4-Pyridinecarboxylicacid,3-ethyl-(9CI);4-Pyridinecarboxylic acid, 3-ethyl-;3-Ethyl-4-pyridine carboxylic acid

Chemical Property of 4-Pyridinecarboxylicacid,3-ethyl-(9CI)

Chemical Property:

• PSA: 50.19000
• LogP: 1.34220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Ethylisonicotinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinecarboxylicacid,3-ethyl-(9CI)

There total 8 articles about 4-Pyridinecarboxylicacid,3-ethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 3-ethyl-4-pyridinecarboxylate (13341-16-7) → 3-ethylpyridine-4-carboxylic acid (4080-54-0)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 6h;

Reference yield: 65.57%

3-ethylpyridine-4-carbonitrile (13341-18-9) → 3-ethylpyridine-4-carboxylic acid (4080-54-0)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 95 ℃; for 5h;

Reference yield: 52.0%

3-ethyl-4-methylpyridine (529-21-5) → 3-ethylpyridine-4-carboxylic acid (4080-54-0)

Guidance literature:

With selenium(IV) oxide; In diphenylether; at 155 - 185 ℃;

DOI:10.1021/acs.jmedchem.8b01158

upstream raw materials:

3-ethylpyridine-4-carbonitrile

3-ethylpyridine N-oxide

3-ethylpyridine

3-ethyl-4-methylpyridine

Downstream raw materials:

3-ethyl isonicotinic acid chloride

N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide

3-ethyl-4-pyridinemethanol

Refernces

• 1、 -. "NON-PEPTIDE OPIOID RECEPTOR MODULATORS". Page/Page column 15. . Retrieved 2020/03/15.
• 2、 Zheng, Yi,Obeng, Samuel,Wang, Huiqun,Jali, Abdulmajeed M.,Peddibhotla, Bharath,Williams, Dwight A.,Zou, Chuanchun,Stevens, David L.,Dewey, William L.,Akbarali, Hamid I.,Selley, Dana E.,Zhang, Yan. "Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands". supporting information. p. 561 - 574. Retrieved 2019/01/30.