Methyl 6-broMo-3-Methoxypicolinate

Base Information

• Chemical Name: Methyl 6-broMo-3-Methoxypicolinate
• CAS No.: 945954-94-9
• Molecular Formula: C8H8BrNO3
• Molecular Weight: 246.06
• Hs Code.: 2933399090
• Mol file: 945954-94-9.mol

Synonyms:methyl 6-bromo-3-methoxypyridine-2-carboxylate;

Chemical Property of Methyl 6-broMo-3-Methoxypicolinate

Chemical Property:

• Boiling Point: 338.2±37.0 °C(Predicted)
• PKA: -1.56±0.10(Predicted)
• PSA: 48.42000
• Density: 1.530±0.06 g/cm3(Predicted)
• LogP: 1.63930
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 6-bromo-3-methoxypicolinate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-broMo-3-Methoxypicolinate

There total 7 articles about Methyl 6-broMo-3-Methoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 6-bromo-3-hydroxypyridine-2-carboxylate (321601-48-3) + methyl iodide (74-88-4) → methyl 6-bromo-3-methoxypyridine-2-carboxylate (945954-94-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 3h;

Reference yield:

6-bromo-3-methoxypyridine-2-carboxylic acid (1256810-26-0) + methyl iodide (74-88-4) → methyl 6-bromo-3-methoxypyridine-2-carboxylate (945954-94-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + methyl 6-bromo-3-hydroxypyridine-2-carboxylate (321601-48-3) → methyl 6-bromo-3-methoxypyridine-2-carboxylate (945954-94-9)

Guidance literature:

In methanol; diethyl ether; at 0 ℃; for 2h;

upstream raw materials:

diazomethane

methyl 6-bromo-3-hydroxypyridine-2-carboxylate

methyl iodide

3-methoxypyridine-2-carboxylic acid methyl ester

Downstream raw materials:

6-bromo-3-methoxypyridine-2-carboxylic acid

6-bromo-3-methoxypicolinaldehyde

C₁₈H₁₈BrF₂N₃O₄S

3-methoxy-6-(trifluoromethyl)picolinic acid

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME". Paragraph 0180; 0183. . Retrieved 2018/01/11.
• 2、 -. "SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES". Page/Page column 39. . Retrieved 2015/01/16.