1-BOC-1,7-DIAZA-SPIRO[4.5]DECANE

Base Information

• Chemical Name: 1-BOC-1,7-DIAZA-SPIRO[4.5]DECANE
• CAS No.: 960294-14-8
• Molecular Formula: C₁₃H₂₄N₂O₂
• Molecular Weight: 240.346
• Hs Code.: 2933990090
• Mol file: 960294-14-8.mol

Synonyms:2-Methyl-2-propanyl 1,7-diazaspiro[4.5]decane-1-carboxylate;

Chemical Property of 1-BOC-1,7-DIAZA-SPIRO[4.5]DECANE

Chemical Property:

• Vapor Pressure: 2.88E-07mmHg at 25°C
• Refractive Index: 1.583
• Boiling Point: 337.028 °C at 760 mmHg
• Flash Point: 157.629 °C
• PSA: 41.57000
• Density: 1.073 g/cm³
• LogP: 2.40620

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl1,7-diazaspiro[4.5]decane-1-carboxylate 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-1,7-DIAZA-SPIRO[4.5]DECANE

There total 15 articles about 1-BOC-1,7-DIAZA-SPIRO[4.5]DECANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl 2-(3-chloropropyl)-2-cyanopyrrolidine-1-carboxylate (960294-13-7) → tert-butyl 1,7-diazaspiro[4.5]decane-1-carboxylate (960294-14-8)

Guidance literature:

With ammonium hydroxide; hydrogen; nickel; In methanol; at 50 ℃; for 6h; under 1551.49 Torr;

DOI:10.1080/00397910701571599

Reference yield:

C20H30N2O2 → 1,7-diazaspiro[4.5]decane-1-carboxylic acid tert-butyl ester (960294-14-8)

Guidance literature:

With hydrogen; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; under 3040.2 Torr;

Reference yield:

tert-butyl 2-carbamoylpyrrolidine-1-carboxylate (54503-10-5) → tert-butyl 1,7-diazaspiro[4.5]decane-1-carboxylate (960294-14-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 85 percent / trifluoroacetic anhydride; triethylamine / CH₂Cl₂ / 0 - 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran / 0.75 h / -78 °C

2.2: 75 percent / tetrahydrofuran / -78 - 20 °C

3.1: 95 percent / H₂; aq. NH₃ / Raney Ni / methanol / 6 h / 50 °C / 1551.49 Torr

With ammonium hydroxide; hydrogen; triethylamine; trifluoroacetic anhydride; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1080/00397910701571599

upstream raw materials:

tert-butyl 2-(3-chloropropyl)-2-cyanopyrrolidine-1-carboxylate

tert-butyl 2-carbamoylpyrrolidine-1-carboxylate

N-tert-butoxycarbonyl-proline

N-tert-butoxycarbonyl-α-cyanopyrrolidine

Refernces

• 1、 Tang,Qu,Xu,Ma,Chen, Shu-Hui,Li. "Practical synthesis of structurally important spirodiamine templates". . p. 3793 - 3799. Retrieved 2008/02/10.