N-Ethylnorlysergic Acid N,N-diethylaMide

Base Information

• Chemical Name: N-Ethylnorlysergic Acid N,N-diethylaMide
• CAS No.: 65527-62-0
• Molecular Formula: C21H27N3O
• Molecular Weight: 337.45900
• Mol file: 65527-62-0.mol

Synonyms:ETH-LAD;6-Ethyl-6-nor-lysergic acid diethylamide;N-Ethylnorlysergic acid N,N-diethylamide;N-EthylnorLSD;

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Chemical Property of N-Ethylnorlysergic Acid N,N-diethylaMide

Chemical Property:

• Appearance/Colour: Brown to Dark Brown Solid
• Boiling Point: 550.0±50.0 °C(Predicted)
• PKA: 17.32±0.40(Predicted)
• PSA: 39.34000
• Density: 1.19±0.1 g/cm3(Predicted)
• LogP: 3.23400

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Ethyl Norlysergic Acid N,N-Diethylamide is a structural analog of Lysergic acid diethylamide (LSD) with possible hallucinogenic effects.

Technology Process of N-Ethylnorlysergic Acid N,N-diethylaMide

There total 4 articles about N-Ethylnorlysergic Acid N,N-diethylaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl iodide (75-03-6) + 8β-6-norlysergic acid diethylamide (35779-43-2) → N6-Ethyl-norlysergic acid diethylamide (65527-62-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 4h;

DOI:10.1021/jm00147a022

Reference yield:

9,10-didehydro-N,N-diethyl-6-cyanoergoline-8β-carboxamide (35779-41-0) → N6-Ethyl-norlysergic acid diethylamide (65527-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / Zn / acetic acid; H₂O / 4 h / Heating

2: 91 percent / K₂CO₃ / dimethylformamide / 4 h / 25 °C

With potassium carbonate; zinc; In water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00147a022

Reference yield:

lysergide (50-37-3) → N6-Ethyl-norlysergic acid diethylamide (65527-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / CCl₄; CHCl₃ / 6 h / Heating

2: 61 percent / Zn / acetic acid; H₂O / 4 h / Heating

3: 91 percent / K₂CO₃ / dimethylformamide / 4 h / 25 °C

With potassium carbonate; zinc; In tetrachloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00147a022

upstream raw materials:

ethyl iodide

8β-6-norlysergic acid diethylamide

9,10-didehydro-N,N-diethyl-6-cyanoergoline-8β-carboxamide

lysergide

Refernces