hexyl aMino(4-aMinophenyl)MethylenecarbaMate hydrochloride

Base Information

• Chemical Name: hexyl aMino(4-aMinophenyl)MethylenecarbaMate hydrochloride
• CAS No.: 1307233-93-7
• Molecular Formula: C14H22ClN3O2
• Molecular Weight: 299.801
• Hs Code.: 2924299090
• Mol file: 1307233-93-7.mol

Synonyms:Hexyl (amino(4-aminophenyl)methylene)carbamate hydrochloride;

Chemical Property of hexyl aMino(4-aMinophenyl)MethylenecarbaMate hydrochloride

Chemical Property:

• PSA: 90.70000
• LogP: 4.77450

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hexyl((4-Aminophenyl)(imino)methyl)carbamateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Hexyl ((4-Aminophenyl)(imino)methyl)carbamate Hydrochloride is the impurity of the antithrombotic drug Dabigatran Etexilate (D100150), which is nonpeptide direct thrombin inhibitor.

Technology Process of hexyl aMino(4-aMinophenyl)MethylenecarbaMate hydrochloride

There total 1 articles about hexyl aMino(4-aMinophenyl)MethylenecarbaMate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

n-hexyl chloroformate (6092-54-2) + 4-aminobenzamidine dihydrochloride (2498-50-2) → 4-aminobenzamidine-N-hexylcarbamate hydrochloride (1307233-93-7)

Guidance literature:

n-hexyl chloroformate; 4-aminobenzamidine dihydrochloride; With sodium hydroxide; In acetone; at 5 - 20 ℃; for 0.25h;

With hydrogenchloride; In water;

Reference yield: 87.8%

N-[[2-(chloromethyl)-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridyl-β-alanine ethyl ester (1307233-94-8) + 4-aminobenzamidine-N-hexylcarbamate hydrochloride (1307233-93-7) → dabigatran etexilate (211915-06-9)

Guidance literature:

4-aminobenzamidine-N-hexylcarbamate hydrochloride; With sodium hydroxide; In acetic acid butyl ester; water; at 50 ℃;

N-[[2-(chloromethyl)-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridyl-β-alanine ethyl ester; With tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; sodium iodide; In acetic acid butyl ester; cyclohexane; water; at 40 ℃; for 2h;

Reference yield: 75.92%

4-aminobenzamidine-N-hexylcarbamate hydrochloride (1307233-93-7) → C14H20N2O3*ClH

Guidance literature:

With hydrogenchloride; at 60 ℃; for 5h; Reagent/catalyst; Temperature;

upstream raw materials:

n-hexyl chloroformate

4-aminobenzamidine dihydrochloride

Downstream raw materials:

dabigatran etexilate

Refernces