2-(Trifluoromethyl)pyridine-4-boronic acid

Base Information

• Chemical Name: 2-(Trifluoromethyl)pyridine-4-boronic acid
• CAS No.: 1093407-58-9
• Molecular Formula: C6H5BF3NO2
• Molecular Weight: 190.917
• Hs Code.: 2933399090
• Mol file: 1093407-58-9.mol

Synonyms:2-(Trifluoromethyl)pyridine-4-boronic acid;2-(TRIFLUOROMETHYL)PYRIDIN-4-YLBORONIC ACID;2-(Trifluoromethyl)pyridine-4-boronic acid 96%;4-Borono-2-(trifluoromethyl)pyridine

Chemical Property of 2-(Trifluoromethyl)pyridine-4-boronic acid

Chemical Property:

• Boiling Point: 285℃
• PKA: 6.56±0.10(Predicted)
• Flash Point: 126℃
• PSA: 53.35000
• Density: 1.44
• LogP: -0.21980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(Trifluoromethyl)pyridine-4-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Trifluoromethyl)pyridine-4-boronic Acid is a useful intermediate in the preparation of 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials.

Technology Process of 2-(Trifluoromethyl)pyridine-4-boronic acid

There total 1 articles about 2-(Trifluoromethyl)pyridine-4-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

Triisopropyl borate (5419-55-6) + 2-(trifluoromethyl)pyridine-4-iodide (590371-73-6) → (2-(trifluoromethyl)pyridin-4-yl)boronic acid (1093407-58-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -10 ℃; for 3.5h; Inert atmosphere;

Reference yield: 72.0%

(2-(trifluoromethyl)pyridin-4-yl)boronic acid (1093407-58-9) + [6-amino-7-carbamoyl-5-(3-methoxy-2,6-dimethyl-phenyl)pyrrolo[2,3-b]pyrazin-2-yl] trifluoromethanesulfonate → 6-amino-5-(3-methoxy-2,6-dimethyl-phenyl)-2-[2-(trifluoromethyl)-4-pyridyl]pyrrolo[2,3-b]pyrazine-7-carboxamide

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 4h; Inert atmosphere;

Reference yield: 71.1%

(2-(trifluoromethyl)pyridin-4-yl)boronic acid (1093407-58-9) + 3-[4-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]-6-fluoro-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1231192-27-0) → 6-fluoro-1-(2,2,2-trifluoroethyl)-3-(4-{4-[2-(trifluoromethyl)pyridin-4-yl]phenyl}-1H-1,2,3-triazol-1-yl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1231191-58-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; at 80 ℃; for 16h;

upstream raw materials:

Triisopropyl borate

2-(trifluoromethyl)pyridine-4-iodide

Downstream raw materials:

(1H-benzo[d]imidazol-2-yl)(4-(3-(2-(trifluoromethyl)pyridin-4-yl)pyrazin-2-yloxy)phenyl)methanone

6-fluoro-1-(2,2,2-trifluoroethyl)-3-(4-{4-[2-(trifluoromethyl)pyridin-4-yl]phenyl}-1H-1,2,3-triazol-1-yl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

N-((3-methyl-2'-(trifluoromethyl)-2,4'-bipyridin-5-yl)methyl)-4-(pyrazin-2-yl)benzamide

5-(3-fluorophenyl)-N-((2'-(trifluoromethyl)-2,4'-bipyridin-S-yl)methyl)picolinamide

Refernces