(6-Methylpyridin-3-yl)methanamine

Base Information

• Chemical Name: (6-Methylpyridin-3-yl)methanamine
• CAS No.: 56622-54-9
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 816-408-4
• DSSTox Substance ID: DTXSID20480764
• Wikidata: Q82315824
• Mol file: 56622-54-9.mol

Synonyms:(6-methylpyridin-3-yl)methanamine;56622-54-9;MFCD06212657;(6-METHYL-3-PYRIDYL)METHANAMINE;3-Pyridinemethanamine, 6-methyl-;5-(Aminomethyl)-2-methylpyridine;SCHEMBL317944;DTXSID20480764;NZPFQOXRHLUPRT-UHFFFAOYSA-N;AB9816;C-(6-methylpyridin-3-yl)methylamine;3-AMINOMETHYL-6-METHYLPYRIDINE;AKOS000169636;PB20145;BS-13047;SY034719;AM20061333;CS-0044724;FT-0684875;EN300-42748;(6-methylpyridin-3-yl)methanamine, AldrichCPR;AB00999699-01;A831127;J-501685;(6-methyl-3-pyridyl)methanamine

Chemical Property of (6-Methylpyridin-3-yl)methanamine

Chemical Property:

• Melting Point: 58-61 °C(Solv: heptane (142-82-5))
• Boiling Point: 90-100 °C(Press: 4 Torr)
• PKA: pK1: 8.70(+1) (30°C)
• PSA: 38.91000
• Density: 1.027±0.06 g/cm3(Predicted)
• LogP: 1.54900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Aminomethyl-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-37/38-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=C(C=C1)CN
• Uses: 3-Aminomethyl-6-methylpyridine is used in the synthesis of non-nucleoside phthalimide derivatives as HIV-1 reverse transcriptase inhibitors. Also used in in the discovery of potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with cytocrhome P450 CYP2C9 inhibitory activity.

Technology Process of (6-Methylpyridin-3-yl)methanamine

There total 10 articles about (6-Methylpyridin-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-methylnicotinonitrile (3222-48-8) → C-(6-methylpyridin-3-yl)methylamine (56622-54-9)

Guidance literature:

With ammonia; hydrogen; In methanol; at 20 ℃; for 2h;

Reference yield: 58.0%

6-methylnicotinamide (6960-22-1) → C-(6-methylpyridin-3-yl)methylamine (56622-54-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 60 ℃; for 24.75h;

Reference yield:

5-(azidomethyl)-2-methylpyridine (474554-80-8) → C-(6-methylpyridin-3-yl)methylamine (56622-54-9)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; for 4h; Reflux;

upstream raw materials:

6-methylnicotinonitrile

2-chloro-6-methylnicotinonitrile

2-hydroxy-6-methylnicotinonitrile

6-methylnicotinamide

Downstream raw materials:

6-methyl-3-pyridinemethanol

C₁₄H₁₄ClN₃O₃S

C₂₀H₁₉N₃O₃S

3-(3-amino-5-chloro-2,6-diethyl-phenyl)-1-(4-ethyl-phenyl)-1-(6-methyl-pyridin-3yl-methyl)-urea

Refernces

• 1、 -. "CANCER TREATMENTS TARGETING CANCER STEM CELLS". Paragraph 0331; 0402-0404. . Retrieved 2019/11/19.
• 2、 -. "NOVEL SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION". Page/Page column 126; 127. . Retrieved 2016/12/01.