PF-04691502

Base Information

• Chemical Name: PF-04691502
• CAS No.: 1013101-36-4
• Molecular Formula: C₂₂H₂₇N₅O₄
• Molecular Weight: 425.487
• Mol file: 1013101-36-4.mol

Synonyms:2-Amino-8-[4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-;

Chemical Property of PF-04691502

Chemical Property:

• Boiling Point: 682.465 °C at 760 mmHg
• PKA: 14.39±0.10(Predicted)
• Flash Point: 366.542 °C
• PSA: 125.38000
• Density: 1.364 g/cm³
• LogP: 2.82650
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Sonicated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

PF 04691502 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: PF-04691502 is an potent and selective inihibitor of PI3K and mTOR Kinases with antitumor activity. PF-04691502 is an potent and selective inihibitor of PI3K and mTOR Kinases with antitumor activity. Potent PI3K/mTOR Dual Inhibitor. PF-04691502 is an ATP-competitive PI3K/mTOR inhibitor with IC50 of 32 nM and also inhibits Akt T308/S473 with IC50 of 7.5 nM/3.8 nM.

Technology Process of PF-04691502

There total 3 articles about PF-04691502 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-amino-6-bromo-8-(cis-4-(2-hydroxyethoxy)cyclohexyl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one + 2-methoxy-pyridine-5-boronic acid (163105-89-3,600726-67-8) → 2-amino-8-(cis-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one (1013101-36-4)

Guidance literature:

With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 100 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

2-{[cis-4-(2-amino-6-bromo-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)cyclohexyl]oxy}acetamide + 2-methoxy-pyridine-5-boronic acid (163105-89-3,600726-67-8) → 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridyl)-4-methyl-pyridino[2,3-d]pyrimidine-7(8H)-one (1013099-86-9,1013101-36-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmcl.2013.02.020

Reference yield:

→ PF-04691502 (1013101-36-4)

Guidance literature:

upstream raw materials:

2-methoxy-pyridine-5-boronic acid

Refernces

• 1、 -. "PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS". Page/Page column 86. . Retrieved 2008/06/13.