3-Iodo-1H-pyrrolo[2,3-c]pyridine

Base Information

• Chemical Name: 3-Iodo-1H-pyrrolo[2,3-c]pyridine
• CAS No.: 956003-24-0
• Molecular Formula: C7H5IN2
• Molecular Weight: 244.03
• Hs Code.: 2933990090
• Mol file: 956003-24-0.mol

Synonyms:1H-Pyrrolo[2,3-c]pyridine, 3-iodo-

Chemical Property of 3-Iodo-1H-pyrrolo[2,3-c]pyridine

Chemical Property:

• Vapor Pressure: 1.18E-05mmHg at 25°C
• Boiling Point: 380.5°C at 760 mmHg
• PKA: 13.16±0.40(Predicted)
• Flash Point: 183.9°C
• PSA: 28.68000
• Density: 2.082g/cm³
• LogP: 2.16750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Iodo-1H-pyrrolo[2,3-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Iodo-1H-pyrrolo[2,3-c]pyridine

There total 1 articles about 3-Iodo-1H-pyrrolo[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

6-azaindole (271-29-4) → 3-iodo-1H-pyrrolo[2,3-c]pyridine (956003-24-0)

Guidance literature:

With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1039/c1ob05586k

Reference yield: 75.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-iodo-1H-pyrrolo[2,3-c]pyridine (956003-24-0) → tert-butyl 3-iodo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate (1174038-59-5)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1039/c1ob05586k

Reference yield:

3-iodo-1H-pyrrolo[2,3-c]pyridine (956003-24-0) + benzenesulfonyl chloride (98-09-9) → 1-benzenesulfonyl-3-iodo-1H-pyrrolo[2,3-c]pyridine (887115-55-1)

Guidance literature:

3-iodo-1H-pyrrolo[2,3-c]pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

benzenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2017.03.037

upstream raw materials:

6-azaindole

Downstream raw materials:

tert-butyl 3-iodo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-c]pyridine

C₂₁H₂₁N₅O₂

2-(5-chloro-2-fluoro-phenyl)-4-[1-(2-methoxy-ethyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-[1,8]naphthyridine

Refernces

• 1、 Shaw, Simon J.,Goff, Dane A.,Lin, Nan,Singh, Rajinder,Li, Wei,McLaughlin, John,Baltgalvis, Kristen A.,Payan, Donald G.,Kinsella, Todd M.. "Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus". supporting information. p. 2617 - 2621. Retrieved 2017/05/10.
• 2、 -. "4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES". Page/Page column 11. . Retrieved 2010/12/18.