methyl 3-methoxy-5-(trifluoromethyl)benzoate

Base Information

• Chemical Name: methyl 3-methoxy-5-(trifluoromethyl)benzoate
• CAS No.: 1003843-90-0
• Molecular Formula: C10H9F3O3
• Molecular Weight: 234.175
• Hs Code.: 2916399090
• Mol file: 1003843-90-0.mol

Synonyms:METHYL 3-METHOXY-5-(TRIFLUOROMETHYL)BENZOATE;Methyl 3-methoxy-5-trifluoromethylbenzoate;

Chemical Property of methyl 3-methoxy-5-(trifluoromethyl)benzoate

Chemical Property:

• PSA: 35.53000
• LogP: 2.50060

Purity/Quality:

≥99% ^*data from raw suppliers

Methyl 3-methoxy-5-(trifluoromethyl)benzoate 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-methoxy-5-(trifluoromethyl)benzoate

There total 1 articles about methyl 3-methoxy-5-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-hydroxy-5-(trifluoromethyl)benzoic acid (328-69-8) + methyl iodide (74-88-4) → 3-methoxy-5-trifluoromethyl-benzoic acid methyl ester (1003843-90-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 20h;

Reference yield: 98.0%

3-methoxy-5-trifluoromethyl-benzoic acid methyl ester (1003843-90-0) → [3-methoxy-5-(trifluoromethyl)phenyl]methanol (916420-98-9)

Guidance literature:

3-methoxy-5-trifluoromethyl-benzoic acid methyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With sodium sulfate; In tetrahydrofuran; diethyl ether;

Reference yield:

3-methoxy-5-trifluoromethyl-benzoic acid methyl ester (1003843-90-0) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 3,N-Dimethoxy-N-methyl-5-trifluoromethylbenzamide (1178585-10-8)

Guidance literature:

3-methoxy-5-trifluoromethyl-benzoic acid methyl ester; N,O-dimethylhydroxylamine*hydrochloride; In tetrahydrofuran; at -15 ℃; Inert atmosphere;

With isopropylmagnesium bromide; In tetrahydrofuran; at -15 - 20 ℃;

upstream raw materials:

3-hydroxy-5-(trifluoromethyl)benzoic acid

methyl iodide

Downstream raw materials:

[3-methoxy-5-(trifluoromethyl)phenyl]methanol

3,N-Dimethoxy-N-methyl-5-trifluoromethylbenzamide

2-bromo-1-[3-methoxy-5-(trifluoromethyl)phenyl]ethanone

1-(3-Methoxy-5-trifluormethylphenyl)ethanone

Refernces

• 1、 -. "TRIAZOLIUM SALTS AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS". Page/Page column 53. . Retrieved 2011/02/26.