4-Chloro-6-aminoquinoline

Base Information

• Chemical Name: 4-Chloro-6-aminoquinoline
• CAS No.: 1085192-91-1
• Molecular Formula: C9H7ClN2
• Molecular Weight: 179
• Hs Code.: 2933499090
• Mol file: 1085192-91-1.mol

Synonyms:4-Chloro-6-aminoquinoline

Chemical Property of 4-Chloro-6-aminoquinoline

Chemical Property:

• PSA: 38.91000
• Density: 1.363
• LogP: 3.05160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloroquinolin-6-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-6-aminoquinoline

There total 5 articles about 4-Chloro-6-aminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-chloro-6-nitro-quinoline-1-oxide (101861-60-3) → 4-chloroquinolin-6-amine (1085192-91-1)

Guidance literature:

4-chloro-6-nitro-quinoline-1-oxide; With hydrogenchloride; tin(ll) chloride; In water; for 1h; Heating;

With ammonia; In water;

DOI:10.1016/j.cclet.2010.10.005

Reference yield:

4-chloro-6-nitroquinoline (13675-94-0) → 4-chloroquinolin-6-amine (1085192-91-1)

Guidance literature:

With ethanol; nickel; Hydrogenation;

DOI:10.1021/ja01150a002

Reference yield:

quinolin-4-ol (611-36-9) → 4-chloroquinolin-6-amine (1085192-91-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid

2: phosphoryl chloride

3: aqueous acetic acid; iron-powder

With sulfuric acid; nitric acid; iron; acetic acid; trichlorophosphate;

DOI:10.1021/ja01194a044

upstream raw materials:

4-chloro-6-nitroquinoline

quinolin-4-ol

4-hydroxy-6-nitro-quinoline

6-nitroquinoline-N-oxide

Refernces

• 1、 -. "AKT3 MODULATORS". Paragraph 0368; 0369. . Retrieved 2021/11/13.