2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-

Base Information

• Chemical Name: 2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-
• CAS No.: 1010096-65-7
• Molecular Formula: C17H17N5O
• Molecular Weight: 307.355
• Mol file: 1010096-65-7.mol

Synonyms:2H-Tetrazole-2-carboxamide, 5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl-;

Chemical Property of 2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-

Chemical Property:

• Boiling Point: 506.103 °C at 760 mmHg
• PKA: -1.73±0.12(Predicted)
• Flash Point: 259.882 °C
• PSA: 63.91000
• Density: 1.22 g/cm³
• LogP: 2.46060

Purity/Quality:

99% ^*data from raw suppliers

5-([1,1''-Biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: LY2183240 is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis. It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain. LY2183240 2’-isomer is a less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively.
• Uses: 5-([1,1''-Biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide is an inhibitor of human monoacylglycerol lipase (hMGL).

Technology Process of 2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-

There total 3 articles about 2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

5-((biphenyl-4-yl)methyl)-1H-tetrazole + N,N-Dimethylcarbamoyl chloride (79-44-7) → 5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide (874902-19-9) + 5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide (1010096-65-7)

Guidance literature:

With triethylamine; In acetonitrile; at 0 ℃; for 15h;

DOI:10.1016/j.ejmech.2007.02.023

Reference yield: 16.0%

5-[(1,1'-biphenyl)-4-ylmethyl]tetrazole + N,N-Dimethylcarbamoyl chloride (79-44-7) → 5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide (874902-19-9) + 5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide (1010096-65-7)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 50 ℃; for 7h;

DOI:10.1016/j.ejmech.2013.01.050

Reference yield:

→ 5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide (874902-19-9) + 5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide (1010096-65-7)

Guidance literature:

upstream raw materials:

N,N-Dimethylcarbamoyl chloride

Refernces

• 1、 -. "INHIBITORS OF FATTY ACID AMIDE HYDROLASE AND MONOACYLGLYCEROL LIPASE FOR MODULATION OF CANNABINOID RECEPTORS". Page/Page column 73. . Retrieved 2009/10/22.