2-(2-hydroxypropan-2-yl)phenol

Base Information

• Chemical Name: 2-(2-hydroxypropan-2-yl)phenol
• CAS No.: 3045-32-7
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Hs Code.: 2907299090
• Mol file: 3045-32-7.mol

Synonyms:2-(2-hydroxypropan-2-yl)phenol;o-Hydroxy-α,α-diMethylbenzyl Alcohol;Benzenemethanol, 2-hydroxy-α,α-dimethyl-;2-(2-HYDROXYPROPAN-2-YL)PHENOL(WX191756)

Chemical Property of 2-(2-hydroxypropan-2-yl)phenol

Chemical Property:

• Melting Point: 41-44 °C
• Boiling Point: 252.7±7.0 °C(Predicted)
• PKA: 10.15±0.35(Predicted)
• PSA: 40.46000
• Density: 1.122±0.06 g/cm3(Predicted)
• LogP: 1.61960
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

o-Hydroxy-α,α-dimethylbenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: o-Hydroxy-α,α-dimethylbenzyl Alcohol is an intermediate in the synthesis of 2,4’-Bisphenol A (B519490), an derivative used for the preparation of low-molecular-weight epoxy resins.

Technology Process of 2-(2-hydroxypropan-2-yl)phenol

There total 20 articles about 2-(2-hydroxypropan-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(1-hydroxy-1-methyl-ethyl)-bicyclo[3.1.0]hex-3-en-2-one → 2-(1-hydroxy-1-methylethyl)phenol (3045-32-7)

Guidance literature:

In chloroform; Irradiation;

DOI:10.1021/ol016506j

Reference yield: 88.0%

methylmagnesium chloride (676-58-4) + methyl salicylate (119-36-8,8024-54-2) → 2-(1-hydroxy-1-methylethyl)phenol (3045-32-7)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 4h;

DOI:10.1021/jo0526284

Reference yield: 64.0%

methyllithium (917-54-4) + o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-(1-hydroxy-1-methylethyl)phenol (3045-32-7)

Guidance literature:

In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 0 - 25 ℃; for 1h;

DOI:10.1016/S0040-4020(98)00985-5

upstream raw materials:

methyl magnesium iodide

diethyl ether

methyl 2-(methoxymethyloxy)benzoate

methyl salicylate

Downstream raw materials:

2,4,4-Trimethyl-4H-benzo[1,3]dioxine

2-(2-hydroxyphenyl)-2-methoxypropane

C₁₂H₁₈O₃

C₂₀H₂₁NO₄

Refernces

• 1、 Brel, V. K.,Mikulenkova, E. A.,Mironov, V. F.,Tatarinov, D. A.,Terekhova, N. V.. "Synthesis of acyclic and cyclic phosphonates based on substituted 2-hydroxybenzylic alcohols". . p. 2147 - 2152. Retrieved 2020/12/09.
• 2、 -. "MODIFIED CYTOSINE POLYNUCLEOTIDE OLIGOMERS AND METHODS". Paragraph 00224; 00228. . Retrieved 2015/11/30.