(1R.2R)-DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE

Base Information

• Chemical Name: (1R.2R)-DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE
• CAS No.: 140459-96-7
• Molecular Formula: C10H16O4
• Molecular Weight: 200.235
• Mol file: 140459-96-7.mol

Synonyms:trans-Cyclohexan-1,2-dicarbonsaeure-dimethylester;trans-Cyclohexan-dicarbonsaeure-1,2-dimethylester;Cyclohexan-1,2-trans-dicarbonsaeure-dimethylester;1R,2R-cyclohexanedicarboxylic acid dimethyl ester;

Chemical Property of (1R.2R)-DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE

Chemical Property:

• PSA: 52.60000
• LogP: 1.13880
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(1R,2R)1,2-CyclohexanedicarboxylicAcid1,2-DimethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (1R,2R)1,2-Cyclohexanedicarboxylic Acid 1,2-Dimethyl Ester is a chemical reagent used in the synthesis of advanced tetracyclic systems.

Technology Process of (1R.2R)-DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE

There total 13 articles about (1R.2R)-DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + (1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid (46022-05-3) → (1R,2R)-1,2-cyclohexanedicarboxylic acid dimethyl ester (140459-96-7)

Guidance literature:

With thionyl chloride; at 20 ℃; for 2h; Reflux;

Reference yield: 75.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid (46022-05-3) → (1R,2R)-1,2-cyclohexanedicarboxylic acid dimethyl ester (140459-96-7)

Guidance literature:

In diethyl ether; at 0 ℃; Inert atmosphere;

DOI:10.1021/jo302467w

Reference yield:

methanol (67-56-1) + (R,R)-1,2-cyclohexane dicarboxylic acid (R)-1-phenylethyl amine salt → (1R,2R)-1,2-cyclohexanedicarboxylic acid dimethyl ester (140459-96-7)

Guidance literature:

With sulfuric acid; at 10 - 50 ℃; for 20h;

upstream raw materials:

dimethyl (R,R)-(-)-trans-1,2-cyclohex-4-ene-1,2-dicarboxylate

diazomethane

(1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid

dimethyl cis-1,2,3,6-tetrahydrophthalate

Downstream raw materials:

(1R,2R)-α,α,α',α'-tetraphenylcyclohexane-1,2-dimethanol

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

(1R,2R)-(-)-trans-cyclohexane-1,2-diylbis(methylene)dimethanesulfonate

1,2-dimethyl cyclohex-2-ene-1,2-dicarboxylate

Refernces

• 1、 Wu, Dehua,Song, Jintong,Qu, Lang,Zhou, Weilan,Wang, Lei,Zhou, Xiangge,Xiang, Haifeng. "Ultralow-Molecular-Weight Stimuli-Responsive and Multifunctional Supramolecular Gels Based on Monomers and Trimers of Hydrazides". supporting information. p. 3370 - 3378. Retrieved 2020/10/02.
• 2、 -. "Chiral organic ligand and preparation method and application of near-infrared rare-earth complex of chiral organic ligand". Paragraph 0030. . Retrieved 2017/09/01.